STRESS-TRIGGERED ABORTION - INHIBITION OF PROTECTIVE SUPPRESSION AND PROMOTION OF TUMOR NECROSIS FACTOR-ALPHA(TNF-ALPHA) RELEASE AS A MECHANISM TRIGGERING RESORPTIONS IN MICE
STRESS-TRIGGERED ABORTION - INHIBITION OF PROTECTIVE SUPPRESSION AND PROMOTION OF TUMOR NECROSIS FACTOR-ALPHA(TNF-ALPHA) RELEASE AS A MECHANISM TRIGGERING RESORPTIONS IN MICE
复制标题
DOI：
10.1111/j.1600-0897.1995.tb01141.x
复制
发表时间：
1995-01-01
影响因子：
3.6
通讯作者：
CLARK, DA
中科院分区：
文献类型：
--
作者：
ARCK, PC;MERALI, FS;CLARK, DA
问题：压力对怀孕结果有不利影响，在动物和人类中都被认为是一种流产原。然而，压力流产的机制在很大程度上是未知的。同种免疫可以预防应激引发的流产，已知免疫可以增加转化生长因子β 2方法：为了研究这些机制，DBA/2 J雄性与CBA/J或C3 H/ HeJ雌性交配，怀孕雌性在怀孕第4.5天至第8.5天暴露于超声声应激24 h。超声波应力显着提高了吸收率，在CBA/J雌性动物中在第5.5天达到峰值，在LPS抗性C3 H/HeJ雌性动物中在第4.5天达到峰值。从蜕膜释放的肿瘤坏死因子-α（TNF-α）也升高，TGF-β 2介导的抑制活性显著降低。只有当TNF-α/TGF-β 2的比例增加时，再吸收率才增加，与control.CONCLUSION：这些数据表明，压力可能会抑制保护性抑制机制，并促进流产细胞因子，如TNF-α的分泌。可能的机制进行了讨论。
PROBLEM: Stress adversely affects pregnancy outcome and has been implicated as an abortogen in both animals and humans. However, the mechanisms whereby stress aborts are largely unknown. Alloimmunization can prevent stress-triggered abortion, and immunization is known to increase transforming growth factor-beta 2 (TGF-beta 2)-related suppressive activity.METHOD: To investigate these mechanisms, DBA/2J males were mated to CBA/J or C3H/ HeJ females, and the pregnant females were exposed to ultrasonic sound stress for a period of 24 h between day 4.5 to 8.5 of pregnancy.RESULTS: Ultrasonic stress significantly elevated the resorption rate with a peak effect on day 5.5 in the CBA/J females and on day 4.5 in the LPS-resistant C3H/HeJ females. The tumor necrosis factor-alpha (TNF-alpha) release from the decidua was also elevated and the TGF-beta 2-mediated suppressive activity was significantly decreased. The resorption rate only increased when the TNF-alpha/TGF-beta 2 ratio was increased compared to the control.CONCLUSION: These data suggest that stress may inhibit protective suppressor mechanisms and promote secretion of abortogenic cytokines such as TNF-alpha. Possible mechanisms are discussed.