The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy.
The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy.
复制标题
677 C-T 亚甲基四氢叶酸还原酶突变并不能预测妊娠期间母体同型半胱氨酸的增加。
DOI：
10.1016/s0029-7844(02)03120-4
复制
发表时间：
2003
影响因子：
7.2
通讯作者：
Roberts,JamesM
中科院分区：
文献类型：
--
作者：
Powers,RobertW;Dunbar,MichaelS;Gallaher,MarciaJ;Roberts,JamesM
为了检验这一假设，即无论是否存在677 CT亚甲基四氢叶酸还原酶（MTHFR）突变，服用含叶酸的产前维生素的妇女的母体同型半胱氨酸浓度不会有显著差异，并在先兆子痫中测试这种关系，因为先兆子痫妊娠中同型半胱氨酸浓度较高。研究了具有和不具有677 CT MTHFR突变的（对照和先兆子痫）。MTHFR基因型对血浆总同型半胱氨酸和血浆叶酸水平的影响无显著性差异（野生型677 CC 8.7±5.6 μM，突变型677 TT 9.0±5.7 μM，P= 0.001）。84)在先兆子痫或正常妊娠中。子痫前期孕妇血浆同型半胱氨酸水平显著高于正常孕妇（10.6±7.3 μM比7.2±3.0 μM，P<0.01）。03)结论677CT MTHFR多态性对大多数服用产前维生素的妇女包括先兆子痫妇女的母体同型半胱氨酸浓度没有显著影响。血浆叶酸水平的增加可能比MTHFR基因型对母体同型半胱氨酸的影响更大。如果同型半胱氨酸被认为是血栓形成倾向的危险因素，则应确定氨基酸的浓度，而不是特定的基因型。
OBJECTIVETo test the hypothesis that, regardless of the presence of the 677 CT methylenetetrahydrofolate reductase (MTHFR) mutation, maternal homocysteine concentrations will not be significantly different in women who are taking prenatal vitamins containing folic acid, and to test this relationship in preeclampsia because homocysteine concentrations are higher in preeclamptic pregnancies.METHODSFifty-seven pregnant white women (control and preeclamptic) with and without the 677 CT MTHFR mutation were studied. Total plasma homocysteine and plasma folic acid were analyzed.RESULTSHomocysteine concentrations were not different by MTHFR genotype (wild type 677 CC 8.7±5.6 μM versus mutant 677 TT 9.0±5.7 μM, P=. 84) in preeclamptic or normal pregnancies. However, mean homocysteine concentrations were significantly increased in preeclamptic pregnancies compared with those in normal pregnancies (10.6±7.3 μM versus 7.2±3.0 μM, P<. 03) as previously reported.CONCLUSIONThe 677 CT MTHFR polymorphism does not significantly affect maternal homocysteine concentrations in most women taking prenatal vitamins including women with preeclampsia. The increase in plasma folic acid likely affects maternal homocysteine more than the MTHFR genotype. If homocysteine is considered a thrombophilia risk factor, the concentration of the amino acid and not a particular genotype should be determined.