The Role of DNA Repair Glycosylase OGG1 in Intrahepatic Cholangiocarcinoma
The Role of DNA Repair Glycosylase OGG1 in Intrahepatic Cholangiocarcinoma
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DOI：
10.21873/anticanres.13465
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发表时间：
2019-06-01
影响因子：
2
通讯作者：
Mori, Masaki
中科院分区：
文献类型：
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作者：
Sakata, Kazuhito;Yoshizumi, Tomoharu;Mori, Masaki
背景/目的：之前的研究报道了氧化应激对各种癌症的影响，但对肝内胆管癌（ICC）的影响尚未完全阐明。因此，本研究的目的是揭示氧化 DNA 损伤和修复酶对 ICC 的影响。材料和方法：通过免疫组织化学方法评估 63 例 ICC 患者切除标本中 8-羟基脱氧鸟苷 (8-OHdG) 和 8-OHdG DNA 糖基化酶 (OGG1) 的水平。结果：OGG1 低表达与肿瘤深度 T4 (p=0.04)、静脉侵犯 (p=0.0005)、淋巴管侵犯 (p=0.03) 和神经周围侵犯 (p=0.03) 相关。与高OGG1表达组相比，低OGG1表达的患者预后明显较差（总生存期：p=0.04，无复发生存期：p=0.02）。与 OGG1 不同，8-OHdG 的表达水平与预后无关。结论：DNA氧化损伤和DNA修复酶可能与ICC进展密切相关。
Background/Aim: The effects of oxidative stress on various carcinomas were reported in previous studies, but those in intrahepatic cholangiocarcinoma (ICC) have not been fully elucidated. The purpose of this study was, thus, to reveal the effects of oxidative DNA damage and repair enzymes on ICC. Materials and Methods: The levels of 8-hydroxydeoxyguanosine (8-OHdG) and 8-OHdG DNA glycosylase (OGG1) were immunohistochemically evaluated in specimens resected from 63 patients with ICC. Results: Low OGG1 expression was related to tumour depth T4 (p=0.04), venous invasion (p=0.0005), lymphatic vessel invasion (p=0.03), and perineural invasion (p=0.03). Compared to the high-OGG1-expression group, patients with low OGG1 expression had a significantly poorer prognosis (overall survival: p=0.04, recurrence-free survival: p=0.02). Unlike for OGG1, the expression levels of 8-OHdG showed no association with prognosis. Conclusion: Oxidative DNA damage and DNA repair enzymes may be closely related to ICC progression.