Keratolimbal allograft in corneal reconstruction
Keratolimbal allograft in corneal reconstruction
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DOI：
10.1038/sj.eye.6700670
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发表时间：
2004-04-01
期刊：
影响因子：
3.9
通讯作者：
Tseng, SCG
中科院分区：
文献类型：
--
作者：
Espana, EM;Di Pascuale, M;Tseng, SCG
角膜上皮SC的补充是患有表现为全LSCD的破坏性眼表疾病的患者重建眼表的关键步骤。KLAL是此类手术之一，对双侧全LSCD患者具有长期跟踪记录和长期随访。这篇综述总结了文献经验，并概述了新的战略，是重要的，以提高这一程序的成功。需要进一步的研究来充分了解同种异体组织移植中保护上皮SC粘附、迁移和存活的生物学过程。
The replenishment of corneal epithelial SC is a crucial step for reconstructing the ocular surface in patients suffering from devastating ocular surface diseases manifesting with total LSCD. KLAL is one of such procedures and has a long track record and a long follow-up for patients with bilateral total LSCD. This review summarizes the literature experiences and outline new strategies that are important to enhance the success of this procedure. Further research is needed to fully understand the biological processes involved in allogeneic tissue transplantation for preserving epithelial SC adhesion, migration, and survival.