The use of vaginal natural progesterone for prevention of preterm birth in IVF/ICSI pregnancies
The use of vaginal natural progesterone for prevention of preterm birth in IVF/ICSI pregnancies
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DOI：
10.1016/j.rbmo.2012.03.013
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发表时间：
2012-08-01
影响因子：
4
通讯作者：
Serour, Gamal I.
中科院分区：
文献类型：
--
作者：
Aboulghar, Mona M.;Aboulghar, Mohamed A.;Serour, Gamal I.
本研究的目的是评估阴道自然孕酮对预防IVF/卵胞浆内单精子注射（ICSI）妊娠早产的作用。进行了一项单中心前瞻性安慰剂对照随机研究。共313例IVF/ICSI妊娠患者随机分为两组，从孕中期开始至37周或分娩，每天使用400 mg阴道天然孕酮或安慰剂治疗。其中单胎妊娠215例，双胎妊娠91例。所有患者的早产风险无显著差异（OR 0.672，95%CI 0.42-1.0）。自然孕酮组单胎妊娠的早产率显著较低（OR 0.53，95%CI 0.28-0.97），双胎妊娠两组间无显著差异（OR 0.735，95%CI 0.36-2）。总之，从孕中期开始给予400 mg阴道天然孕酮可降低单胎IVF/ICSI妊娠的早产发生率，但对双胎IVF/ICSI妊娠无影响。RBMOnline（c）2012，生殖保健有限公司。由爱思唯尔有限公司出版。保留所有权利。
The aim of this study was to evaluate the effect of vaginal natural progesterone on the prevention of preterm birth in IVF/intracytoplasmic sperm injection (ICSI) pregnancies. A single-centre prospective placebo-controlled randomized study was performed. A total of 313 IVF/ICSI pregnant patients were randomized into two groups for either treatment with daily 400 mg vaginal natural progesterone or placebo, starting from mid-trimester up to 37 weeks or delivery. Amongst the patients, there were 215 singleton and 91 twin pregnancies. There was no significant difference in risk of preterm birth among all patients (OR 0.672, 95% CI 0.42-1.0. There was a significantly lower preterm birth rate in singleton pregnancies in the natural progesterone arm (OR 0.53, 95% CI 0.28-0.97) and no significant difference between both arms in twin pregnancies (OR 0.735, 95% CI 0.36-2). In conclusion, the administration of 400 mg vaginal natural progesterone from mid trimester reduced the incidence of preterm birth in singleton, but not in twin, IVF/ICSI pregnancies. RBMOnline (c) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.