The predictive value of laboratory tests in oro-maxillofacial infection of different severity
The predictive value of laboratory tests in oro-maxillofacial infection of different severity
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DOI：
10.1111/odi.14590
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发表时间：
2023-04-24
期刊：
影响因子：
3.8
通讯作者：
Shi，Huan
中科院分区：
文献类型：
--
作者：
Wang，Baoli;Zhou，Qin;Shi，Huan
我们的目的是探讨个别实验室检查和组合的测试预测疾病severity.MethodsWe回顾性分析了62例口腔颌面部头颈部间隙感染的价值。根据严重程度将患者分为三组。结果随着感染严重程度的增加，白细胞、中性粒细胞、C反应蛋白（CRP）、降钙素原（PCT）、可溶性白细胞介素受体（SILR）2、IL 6和肌酐（CR）均升高。在第1组（中度感染）与第2组（重度感染）的ROC分析中，白细胞（AUC = 0.724）、中性粒细胞（AUC = 0.714）、PCT（AUC = 0.762）和3种检测组合（AUC = 0.768）的曲线下面积（AUC）值表明具有较强的预测价值。此外，在第2组的ROC分析中，（严重感染）与第3组（极重度感染），CRP的AUC值（AUC = 0.84），PCT（AUC = 0.799），sIL 2R（AUC = 0.937），IL 6（AUC = 0.863）和四项试验的组合（AUC = 0.943）提示有较强的预测价值。CRP、PCT、sIL 2 R和/或IL 6与发生在口腔颌面部和颈部的极重度感染相关。
ObjectiveWe aimed to investigate the value of individual laboratory tests and combinations of tests for predicting disease severity.MethodsWe retrospectively reviewed 62 patients with space infections in the oral and maxillofacial head and neck regions. Patients were divided into three groups according to severity. Laboratory tests associated with disease severity were identified.ResultsAs the severity of infection increased, leukocytes, neutrophils, C‐reactive protein (CRP), procalcitonin (PCT), soluble interleukin receptor (sILR) 2, IL6, and creatinine (CR) increased. In the ROC analysis of group 1 (moderate infection) versus group 2 (severe infection), the area under the curve (AUC) values for leukocytes (AUC = 0.724), neutrophils (AUC = 0.714), PCT (AUC = 0.762) and a combination of the 3 tests (AUC = 0.768) suggested a strong predictive value. Furthermore, in the ROC analysis of group 2 (severe infection) versus group 3 (extremely severe infection), the AUC values for CRP (AUC = 0.84), PCT (AUC = 0.799), sIL2R (AUC = 0.937), IL6 (AUC = 0.863) and a combination of the four tests (AUC = 0.943) suggested a strong predictive value.ConclusionsLeukocytes, neutrophils, and PCT were associated with multispace infection and high severity. CRP, PCT, sIL2R, and/or IL6 were associated with extremely severe infections occurring in the oral and maxillofacial head and neck regions.