CCR5 Proinflammatory Allele in Prostate Cancer Risk
CCR5 Proinflammatory Allele in Prostate Cancer Risk
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DOI：
10.1111/j.1749-6632.2008.03691.x
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Caruso, Calogero
中科院分区：
文献类型：
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作者：
Balistreri, Carmela Rita;Carruba, Giuseppe;Caruso, Calogero
前列腺癌（PCa）是西方国家老年男性中最常见的恶性肿瘤。受影响的老年男性人数正在增加。因此，预防前列腺癌的策略至关重要。为此，了解这种恶性肿瘤的发展和进展机制是至关重要的。近年来，越来越多的遗传学和流行病学研究提出了前列腺癌发生的新假说。有人认为，遗传因素以及暴露于环境因素，如感染因子，饮食致癌物，和激素失衡参与PCa的发展。此外，慢性炎症在PCa中起关键作用。考虑到这种复杂的情况下，在本研究中，我们评估是否CCR5 Delta 32缺失的CCR5基因可能与前列腺癌的易感性。对于对照组，我们使用百岁老人，因为他们代表了一个无病的人类模型。这些初步结果表明，CCR5 Delta 32抗炎变体可能是PCa发展的抵抗因子。
Prostate cancer (PCa) is the most common malignant neoplasm in older men in Western countries. The number of affected older men is increasing. Therefore, strategies for prevention of prostate cancer are crucial. To this purpose it is essential to know the mechanisms involved in development and progression of this malignancy. Recently, an increasing body of genetic and epidemiological studies proposed new hypotheses for prostate carcinogenesis. It has been suggested that genetic factors as well as exposure to environmental factors such as infectious agents, dietary carcinogens, and hormonal imbalances participate in PCa development. Besides, chronic inflammation plays a key role in PCa. Taking into consideration this complex scenario, in the present study we evaluated whether CCR5 Delta 32 deletion of CCR5 gene might be associated with PCa susceptibility. For the control group we used centenarians, since they represent a disease-free human model. These preliminary results suggest that the CCR5 Delta 32 anti-inflammatory variant might be a resistance factor for the development of PCa.