Hybrid Bio-Mag-MEMS combining magnetophoresis and dielectrophoresis
Hybrid Bio-Mag-MEMS combining magnetophoresis and dielectrophoresis
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DOI：
10.1140/epjb/e2013-30679-1
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发表时间：
2013-04-01
影响因子：
1.6
通讯作者：
Reyne, Gilbert
中科院分区：
文献类型：
--
作者：
Blaire, Guillaume;Masse, Alain;Reyne, Gilbert
提出了一种新型生物混合磁MEMS（Bio-Mag-MEMS）的设计。它结合了磁电泳、介电泳和微流体技术。这些现象被用来对磁性标记和非标记的物体进行分类。磁性物体是通过使用高梯度磁泳来捕获的。由于介电泳，这些物体一旦被捕获，就可以成功地在缓冲液中释放。通过使用磁珠，在该混合Bio-Mag-MEMS中进行有效的分选。证明了高分选效率。用解析法和有限元法对微流控通道中的磁场力、斯托克斯力和介电泳力进行了数值模拟。磁标记的对象的轨迹进行了模拟。最后详细介绍了该器件的制作和优化。
The design of a new hybrid magnetic MEMS for biology (Bio-Mag-MEMS) is presented. It combines magnetophoresis, dielectrophoresis and microfluidics. These phenomena are used to sort magnetically tagged and non-tagged objects. Magnetic objects are trapped by the use of high gradient magnetophoresis. Thanks to dielectrophoresis these objects, once trapped, can be successfully released in a buffer. Efficient sorting is performed in this hybrid Bio-Mag-MEMS by using magnetic beads. A high sorting efficiency is demonstrated. Magnetic, Stokes and dielectrophoretic forces in the microfluidic channel are simulated with both analytical tools and the finite element method (FEM). The trajectories of magnetically tagged objects are simulated. Finally the fabrication and optimization of this device are detailed.