Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats
Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats
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DOI：
10.1016/j.nucmedbio.2004.02.008
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发表时间：
2004-08-01
影响因子：
3.1
通讯作者：
Saji, H
中科院分区：
文献类型：
--
作者：
Temma, T;Magata, Y;Saji, H
用[C-14]碘安替比林测定小动物脑血流量的技术非常复杂，因此需要一种简便实用的方法。本文以注射N-异丙基-p-[I-125]碘苯丙胺（IMP）后5 min的微分摄取率（DUR）作为正常大鼠脑血流量的指标，并与[O-15] H_2O和动态PET扫描定量测定的CBF值进行比较。获得了两个值之间的良好相关性。结果表明，[125 I] IMP在大鼠注射后5分钟的DUR是一个有用的和实用的CBF指标，因为既不需要动脉血采样，也不需要代谢物校正。(C)2004年爱思唯尔公司All rights reserved.
Since a very complicated technique is necessary to measure cerebral blood flow (CBF) with [C-14] iodoantipyrine in small animals, a practical and easy method is needed. In this paper, the differential uptake ratio (DUR) at 5 min after injection of N-isopropyl-p-[I-125] iodoamphetamine (IMP) was estimated as an index of CBF in normal rats and compared with the quantitative CBF value measured using [O-15]H2O and dynamic PET scan. A good correlation between the two values was obtained. The results indicate that DUR of [125I] IMP at 5 min after injection in rats is a useful and practical indicator of CBF since neither arterial blood sampling nor metabolite correction is necessary. (C) 2004 Elsevier Inc. All rights reserved.