Membrane trafficking and remodeling at the host-parasite interface.
Membrane trafficking and remodeling at the host-parasite interface.
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DOI：
10.1016/j.mib.2017.11.013
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发表时间：
2017-12
影响因子：
5.4
通讯作者：
J. Santi-Rocca;N. Blanchard
中科院分区：
文献类型：
--
作者：
J. Santi-Rocca;N. Blanchard
重点介绍宿主-寄生虫界面形成膜小管和囊泡（TVN）。TVN与多种宿主膜运输途径相交。TVN通过促进宿主营养物质、蛋白质和脂质的摄取而有益于寄生虫。TVN捕获宿主和寄生虫分子干扰免疫反应。膜形状与许多细胞过程功能相关。含有弓形虫和顶复疟原虫的空泡的界膜位于宿主-寄生虫界面。这种膜包括液泡内和液泡外的小管泡状变形，影响宿主-寄生虫的串扰。在这里，强调T。在弓形虫和疟原虫的背景下，我们提出了最近的研究结果空泡膜重塑及其在寄生虫健身和免疫识别的潜在作用。我们回顾特别是在诱捕和/或运输主机和寄生虫组件的管状泡状结构的影响。了解膜重塑如何影响宿主-病原体相互作用，预计将在对抗寄生虫以外的许多细胞内病原体的斗争中至关重要。
HighlightsHost–parasite interface is shaped into membranous tubules and vesicles (TVN).TVN intersects with a variety of host membrane trafficking pathways.TVN benefits parasite by facilitating uptake of host nutrients, proteins and lipids.TVN trapping of host and parasite molecules interferes with immune responses.Membrane shape is functionally linked with many cellular processes. The limiting membrane of vacuoles containing Toxoplasma gondii and Plasmodium apicomplexan parasites lies at the host–parasite interface. This membrane comprises intra-vacuolar and extra-vacuolar tubulo-vesicular deformations, which influence host–parasite cross-talk. Here, underscoring specificities and similarities between the T. gondii and Plasmodium contexts, we present recent findings about vacuolar membrane remodeling and its potential roles in parasite fitness and immune recognition. We review in particular the implication of tubulo-vesicular structures in trapping and/or transporting host and parasite components. Understanding how membrane remodeling influences host–pathogen interactions is expected to be critical in the battle against many intracellular pathogens beyond parasites.