Strain dependence of muramyl dipeptide-induced LAF(IL 1) release by murine-adherent peritoneal cells.
Strain dependence of muramyl dipeptide-induced LAF(IL 1) release by murine-adherent peritoneal cells.
复制标题
胞壁酰二肽诱导小鼠贴壁腹膜细胞释放 LAF（IL 1）的应变依赖性。
作者：
O. Abehsira‐Amar;C. Damais;M. Parant;L. Chedid
观察了MDP刺激不同品系小鼠腹膜贴壁细胞（APC）产生LAF（IL 1）的能力。MDP可刺激DBA/2、C57 B1/6和CBA/CA小鼠产生巯基乙酸诱导的APC，但对C3 H小鼠无明显作用。DBA/2或C3 H/HeJ小鼠的常驻APC也分别对MDP产生LAF（IL 1）有反应和无反应，在消炎痛存在下，MDP对DBA/2细胞的积极作用更加明显。由于LPS高应答C3 H亚株（C3 HeB/Fe）对MDP无应答，因此得出结论，MDP和LPS诱导LAF（IL 1）的菌株依赖性不相关。此外，C3 H小鼠对MDP的无反应性与其MHC单倍型无关，因为第二个H-2k品系（CBA/CA）对MDP刺激有良好的反应。
The capacity of MDP to stimulate LAF(IL 1) production by adherent peritoneal cells (APC) from different strains of mice was examined. It was observed that MDP could stimulate thioglycollate-induced APC from DBA/2, C57B1/6, and CBA/CA mice, but not from C3H mice. Resident APC from DBA/2 or C3H/HeJ mice were also responders and nonresponders, respectively, to MDP for LAF(IL 1) production, the positive effect of MDP being more marked on DBA/2 cells in the presence of indomethacin. Because a LPS high-responder C3H substrain (C3HeB/Fe) did not respond to MDP, it was concluded that the strain dependence with respect to the induction of LAF(IL 1) seen with both MDP and LPS was not linked. Moreover, the unresponsiveness of C3H mice to MDP was not linked to their MHC haplotype, because a second H-2k strain (CBA/CA) was a good responder to MDP stimulation.