Physiological complexity, aging, and the path to frailty.
Physiological complexity, aging, and the path to frailty.
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DOI：
10.1126/sageke.2004.16.pe16
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发表时间：
2004-04
期刊：
影响因子：
--
通讯作者：
L. Lipsitz
中科院分区：
文献类型：
--
作者：
L. Lipsitz
健康的生理过程需要多个控制系统在多个时间尺度上的复杂相互作用。这些过程的输出（例如，心率、血压、荷尔蒙节律或姿势摇摆）显示出复杂的可变性，可以使用源自非线性动力学领域的分形概念来量化。复杂的生理动力学使生物体能够对日常生活中的内部和外部扰动迅速作出反应。衰老和疾病与许多生理系统动力学复杂性的丧失有关。这种复杂性的丧失可能会降低适应压力的能力，导致虚弱综合症。
Healthy physiological processes require the complex interaction of multiple control systems operating over multiple time scales. The output of these processes (for example, heart rate, blood pressure, hormonal rhythms, or postural sway) demonstrates complex variability that can be quantified using the concept of fractals, derived from the field of nonlinear dynamics. Complex physiological dynamics enable an organism to rapidly respond to the internal and external perturbations of everyday life. Aging and disease are associated with a loss of complexity in the dynamics of many physiological systems. This loss of complexity may reduce the ability to adapt to stress and lead to the syndrome of frailty.