Ambient Particulate Air Pollution and EctopyThe Environmental Epidemiology of Arrhythmogenesis in Women's Health Initiative Study, 1999-2004
Ambient Particulate Air Pollution and EctopyThe Environmental Epidemiology of Arrhythmogenesis in Women's Health Initiative Study, 1999-2004
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DOI：
10.1080/15287390802445483
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发表时间：
2009-01-01
影响因子：
2.6
通讯作者：
Anderson, Garnet
中科院分区：
文献类型：
--
作者：
Liao, Duanping;Whitsel, Eric A.;Anderson, Garnet
研究了环境PM2.5和PM10与心律失常的关系以及吸烟对心律失常的影响。来自美国环境保护署（EPA）空气质量监测器的数据和一个既定的全国范围内，对数正态克里格方法被用来空间估计每日平均浓度的PM在地址的57,422个人从59个检查点在美国24个州在1999年至2004年。急性和亚急性暴露量估计为平均值，在心电图（ECG）前0-2天，平均超过30天（Lag 0; Lag 1; Lag 2; Lag 1 -30）的地理编码特定地址PM浓度。在标准12导联静息心电图检查时，参与者的平均年龄（SD）为67.5（6.9）岁（84%为非西班牙裔白色人; 6%目前吸烟; 15%患有冠心病; 5%患有异位）。在确定了显著的效应修饰因子后，使用两阶段随机效应模型计算PM浓度每增加10 g/m3心律失常的中心合并比值比和95%置信区间（OR，95%CI）。在目前吸烟者中，Lag 0和Lag 1 PM浓度与心室异位（VE）显著相关，在Lag 1 PM 2.5和PM 10时，目前吸烟者中VE的OR（95%CI）分别为2（1.32-3.3）和1.32（1.07-1.65）。当前吸烟和急性暴露（Lag 0; Lag 1; Lag 2）之间的相互作用与VE的关系显着。急性暴露与室上性异位（SVE）或非吸烟者中的VE无显著相关性。亚急性（Lag 1 -30）暴露与心律失常无显著相关性。急性PM2.5和PM10暴露与吸烟者中VE的几率直接相关，这表明他们更容易受到PM的致癌效应的影响。
The relationships between ambient PM2.5 and PM10 and arrhythmia and the effect modification by cigarette smoking were investigated. Data from U.S. Environmental Protection Agency (EPA) air quality monitors and an established national-scale, log-normal kriging method were used to spatially estimate daily mean concentrations of PM at addresses of 57,422 individuals from 59 examination sites in 24 U.S. states in 1999-2004. The acute and subacute exposures were estimated as mean, geocoded address-specific PM concentrations on the day of, 0-2 d before, and averaged over 30 d before the electrocardiogram (ECG) (Lag0; Lag1; Lag2; Lag1-30). At the time of standard 12-lead resting ECG, the mean age (SD) of participants was 67.5 (6.9) yr (84% non-Hispanic White; 6% current smoker; 15% with coronary heart disease; 5% with ectopy). After the identification of significant effect modifiers, two-stage random-effects models were used to calculate center-pooled odds ratios and 95% confidence intervals (OR, 95% CI) of arrhythmia per 10 g/m3 increase in PM concentrations. Among current smokers, Lag0 and Lag1 PM concentrations were significantly associated ventricular ectopy (VE)the OR (95% CI) for VE among current smokers was 2 (1.32-3.3) and 1.32 (1.07-1.65) at Lag1 PM2.5 and PM10, respectively. The interactions between current smoking and acute exposures (Lag0; Lag1; Lag2) were significant in relationship to VE. Acute exposures were not significantly associated with supraventricular ectopy (SVE), or with VE among nonsmokers. Subacute (Lag1-30) exposures were not significantly associated with arrhythmia. Acute PM2.5 and PM10 exposure is directly associated with the odds of VE among smokers, suggesting that they are more vulnerable to the arrhythmogenic effects of PM.