Chitosan does not reduce post-prandial urinary oxalate excretion.
Chitosan does not reduce post-prandial urinary oxalate excretion.
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壳聚糖不会减少餐后尿草酸盐的排泄。
DOI：
10.1007/s00240-006-0048-2
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发表时间：
2006
影响因子：
--
通讯作者：
Goldfarb,DavidS
中科院分区：
文献类型：
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作者：
Wolf,Joshua;Asplin,JohnR;Goldfarb,DavidS
壳聚糖是一种带正电荷的不可吸收的纤维素样纤维状生物聚合物，来源于贝类，其形成具有带负电荷表面的膜。我们推测，带负电荷的草酸盐在肠腔可以连接到带正电荷的叔氨基的壳聚糖。我们研究了壳聚糖对肠道草酸盐吸收的影响，通过测量尿草酸排泄后，口服草酸负荷与不伴随口服壳聚糖。受试者在控制和实验方案期间，分阶段食用固定的饮食并收集24小时的尿液。用HCl和百里酚作为防腐剂收集尿液。在对照期，受试者午餐时摄入草酸盐负荷，即50 g煮熟的菠菜和水;餐后尿液收集分为3个2 h的时间段。对于实验期，1周后，受试者食用与对照期相同的饮食，但在草酸负荷中添加2 g壳聚糖。餐后尿草酸盐排泄量表示为mg草酸盐/g肌酐。菠菜负荷与对照期间25.7±12.8 mg/g肌酐的餐后尿草酸盐显著增加相关。伴随草酸负荷与壳聚糖耐受良好。在实验期间，餐后尿草酸排泄量没有减少：草酸排泄量增加了31.3±16.9 mg/g肌酐（P=0.57，NS）。我们的结论是，壳聚糖不减少急性肠道草酸盐吸收，因此不影响餐后尿草酸排泄。
Chitosan is a positively charged non-absorbable cellulose-like fibrillar biopolymer derived from shellfish which forms films with negatively charged surfaces. We hypothesized that negatively charged oxalate in the intestinal lumen could attach to the positively charged tertiary amino group of chitosan. We studied the effects of chitosan on intestinal oxalate absorption by measuring urinary oxalate excretion following an oral oxalate load with and without accompanying oral chitosan. The subjects consumed a fixed diet and collected urine for 24 h, in divided periods, during control and experimental protocols. Urine was collected with HCl and thymol as a preservative. For the control period, the subjects consumed an oxalate load, 50 g of cooked spinach, with water for lunch; the post-prandial urine collection was divided into three periods of 2 h. For the experimental period, 1 week later, the subjects consumed the same diet as that during the control period, but added 2 g of chitosan to the oxalate load. Post-prandial urinary oxalate excretion was expressed as mg oxalate/g creatinine. The spinach load was associated with a significant post-prandial increase in urinary oxalate during the control period of 25.7±12.8 mg/g creatinine. Accompanying the oxalate load with chitosan was well tolerated. There was no decrease in post-prandial urinary oxalate excretion during the experimental period: oxalate excretion rose by 31.3±16.9 mg/g creatinine (P=0.57, NS). We conclude that chitosan does not reduce acute intestinal oxalate absorption and therefore does not affect post-prandial urinary oxalate excretion.