Unconjugated hyperbilirubinemia and early childhood caries in a diverse group of neonates.
Unconjugated hyperbilirubinemia and early childhood caries in a diverse group of neonates.
复制标题
不同新生儿群体中的非结合高胆红素血症和儿童早期龋齿。
DOI：
10.1055/s-0029-1243314
复制
发表时间：
2010
影响因子：
2
通讯作者：
Benzley,LayneP
中科院分区：
文献类型：
--
作者：
Amin,SanjivB;Karp,JeffreyM;Benzley,LayneP
我们评估了儿童早期龋齿的发展是否与出生后前2周内非结合型高胆红素血症的严重程度相关。我们进行了一项回顾性病例对照研究，研究对象是在新生儿重症监护病房住院数年后由儿科牙医进行全面牙科检查的6岁以下儿童。排除标准包括遗传性疾病、腭裂、直接高胆红素血症和黄疸相关信息缺失。儿童早期患龋与无龋齿的围产期和新生儿的临床变量进行了比较。76名儿童符合研究标准。76名儿童中，42名儿童患有幼儿龋齿，34名儿童乳牙列健康。在临床变量中，只有种族和峰值血清总胆红素浓度在两组之间的双变量分析中有显著差异。在逻辑回归分析中，血清总胆红素峰值浓度与儿童早期龋齿显著相关（校正比值比1.17，95%置信区间1.04 ~ 1.32）。新生儿非结合型高胆红素血症可能与儿童早期龋齿有关。
We evaluated if the development of early childhood caries is associated with the severity of unconjugated hyperbilirubinemia during the first 2 weeks after birth. We performed a retrospective case-control study of children less than 6 years of age seen for comprehensive dental examination by pediatric dentists years following a hospital stay in the neonatal intensive care unit. Exclusion criteria included genetic disorders, cleft palate, direct hyperbilirubinemia, and missing information on jaundice. Children with early childhood caries were compared with those without dental caries for a panel of perinatal and neonatal clinical variables. Seventy-six children met study criteria. Of 76 children, 42 children had early childhood caries, while 34 children had healthy primary dentitions. Among clinical variables, only race and peak total serum bilirubin concentration differed significantly between the two groups on bivariate analysis. On logistic regression, peak total serum bilirubin concentration was significantly associated with early childhood caries (adjusted odds ratio 1.17, 95% confidence interval 1.04 to 1.32). Neonatal unconjugated hyperbilirubinemia may be associated with early childhood caries in children.