Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease.
Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease.
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发表时间：
1997-07
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通讯作者：
Alfonso Dueñas-González;Carlos M. Isales;M. M. Abad-Hernández-M.;Rogelio González-Sarmiento;O. Sangueza;J. Rodriguez-Commes
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作者：
Alfonso Dueñas-González;Carlos M. Isales;M. M. Abad-Hernández-M.;Rogelio González-Sarmiento;O. Sangueza;J. Rodriguez-Commes
乳腺癌的特点是能够迅速转移。可能促进这种转移潜能的因素包括肿瘤血管。一氧化氮（NO）是由一氧化氮合酶（NOS）合成的一种不稳定化合物，不仅是生理性血管张力的主要调节剂，而且是与许多肿瘤相关的血管异常的主要调节剂。为了检验NOS是否在乳腺原发肿瘤中表达及其表达是否与转移有关，我们分析了22例乳腺原发肿瘤中可诱导的NOS的表达，并研究了其与肿瘤细胞转移能力相关的其他基因产物的关系，我们将可诱导的NOS的表达与nm23蛋白（推定的抗转移基因nm23的产物）的表达进行了关联。我们发现NOS的存在与腋窝淋巴结转移之间以及NOS与nm23蛋白缺失之间存在非常强的相关性。这些数据表明NO的合成以及由此导致的肿瘤血流量的增加在促进肿瘤转移中发挥了作用。
Breast cancer is characterized by its ability to metastasize rapidly. Factors that might facilitate this metastatic potential include tumor vascularity. Nitric oxide (NO), a labile compound synthesized by NO synthase (NOS), is a major regulator not only of physiologic vascular tone but also of the abnormal vascularity associated with many tumors. To test whether NOS is expressed in primary breast tumors and whether its expression is associated with the presence of metastasis, we analyzed the expression of the inducible NOS in 22 primary breast tumors, and to investigate its association to other gene products related to the metastatic ability of tumor cells, we correlated the expression of the inducible NOS with the expression of the nm23 protein (the product of the putative antimetastatic gene nm23). We found a very strong correlation between the presence of NOS and axillary lymph node metastasis and between NOS and the absence of nm23 protein. These data suggest that NO synthesis and the resulting increase in blood flow to the tumor play a role in the facilitation of tumor metastasis.