Carnosine protects the brain of rats and mongolian gerbils against ischemic injury: After-stroke-effect
Carnosine protects the brain of rats and mongolian gerbils against ischemic injury: After-stroke-effect
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DOI：
10.1007/s11064-005-8799-7
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发表时间：
2005-10-01
影响因子：
4.4
通讯作者：
Boldyrev, A
中科院分区：
文献类型：
--
作者：
Dobrota, D;Fedorova, T;Boldyrev, A
肌肽是脊椎动物兴奋组织的一种特殊成分，在缺血性发作前给予动物，对缺血再灌注损伤的大脑表现出显着的抗氧化保护作用。在这项研究中，在实验性全脑缺血引起的缺血发作后，评估了肌肽对动物腹膜内给药（100 mg/kg 体重）的治疗效果。在缺血发作后长期（7-14天）再灌注下用肌肽治疗动物表明其对神经系统症状和动物死亡率具有显着的保护作用。肌肽还可以防止脑膜结构的较高脂质过氧化，并增加神经元膜对体外诱导的氧化的抵抗力。脑匀浆中丙二酰二醛 (MDA) 的测量显示，脑中风后动物中丙二醛 (MDA) 水平增加，而脑中风后用肌肽治疗的动物中丙二醛 (MDA) 水平降低。我们得出的结论是，肌肽可以补偿因缺血性损伤而受损的大脑抗氧化防御系统的缺陷。所提供的数据表明肌肽可有效保护缺血后的大脑。
Carnosine, a specific constituent of excitable tissues of vertebrates, exhibits a significant antioxidant protecting effect on the brain damaged by ischemic-reperfusion injury when it was administered to the animals before ischemic episode. In this study, the therapeutic effect of carnosine was estimated on animals when this drug was administered intraperitoneally (100 mg/kg body weight) after ischemic episode induced by experimental global brain ischemia. Treatment of the animals with carnosine after ischemic episode under long-term (7-14 days) reperfusion demonstrated its pronounced protective effect on neurological symptoms and animal mortality. Carnosine also prevented higher lipid peroxidation of brain membrane structures and increased a resistance of neuronal membranes to the in vitro induced oxidation. Measurements of malonyl dialdehyde (MDA) in brain homogenates showed its increase in the after brain stroke animals and decreased MDA level in the after brain stroke animals treated with carnosine. We concluded that carnosine compensates deficit in antioxidant defense system of brain damaged by ischemic injury. The data presented demonstrate that carnosine is effective in protecting the brain in the post-ischemic period.