Risk of breast cancer in relation to antibiotic use
Risk of breast cancer in relation to antibiotic use
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DOI：
10.1002/pds.1512
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发表时间：
2008-02-01
影响因子：
2.6
通讯作者：
Collet, Jean-Paul
中科院分区：
文献类型：
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作者：
Tamim, Hani M.;Hanley, James A.;Collet, Jean-Paul
关于抗生素暴露与乳腺癌风险之间的关系，文献中存在相互矛盾的结果。本研究的目的是评估这种关联使用人口为基础的approach.Methods的源人口是动态队列成员在萨斯喀彻温省处方药计划（加拿大）之间的1981年和2000年。四个匹配的对照组被选为萨斯喀彻温省癌症机构确定的每一个案件，使用发病率密度抽样。诊断前至少15年的详细药物暴露允许研究抗生素使用剂量和时间对乳腺癌风险的各自影响。使用了两种抗生素暴露定义：处方数量和单位数量（片剂、胶囊等），结果共纳入3099例乳腺癌患者和12396例对照者。在索引日期前1-15年内接受更多抗生素处方的受试者中，乳腺癌的发生率较高（四个四分位数的RR分别为1.50、1.63、1.71和1.79，p趋势= 0.0001）。当考虑一些单元时，发现了类似的结果。我们没有发现抗生素暴露时间对乳腺癌风险的任何影响。乳腺癌的风险增加的类似模式被检测到特定的抗生素classes.Conclusions我们观察到一个剂量依赖性增加乳腺癌的风险与抗生素暴露在过去的15年。然而，缺乏时间趋势和缺乏类特定的影响表明一个非因果关系。版权所有（C）2007约翰威利父子有限公司
Background There are conflicting results in the literature regarding the association between the antibiotic exposure and breast cancer risk. The aim of this study was to assess this association using a population-based approach.Methods The source population was the dynamic cohort defined by membership in the Saskatchewan Prescription Drug Plan (Canada) between the years 1981 and 2000. Four matched controls were selected for each case identified by the Saskatchewan Cancer Agency, using incidence density sampling. Detailed drug exposure over a minimum of 15 years before diagnosis allowed studying the respective effects of dosage and timing of antibiotic use on breast cancer risk. Two antibiotic exposure definitions were used: the number of prescriptions and the number of units (tablets, capsules, etc.), which were further categorized into quartiles.Results A total of 3099 breast cancer cases and 12 396 matched controls were included. The incidence of breast cancer was higher in subjects who had more antibiotic prescriptions during the 1-15 years prior to the index date (RRs = 1.50, 1.63, 1.71 and 1.79 for the four quartiles, respectively, p-trend = 0.0001). Similar results were found when a number of units were considered. We did not find any effect of the timing of antibiotic exposure on breast cancer risk. Similar patterns of increased risk of breast cancer were detected for the specific antibiotic classes.Conclusions We observed a dose-dependent increase in breast cancer risk in association with the antibiotic exposure up to 15 years in the past. However, the lack of temporal trends and the absence of class-specific effects suggest a non-causal relationship. Copyright (C) 2007 John Wiley & Sons, Ltd.