Androgen Abuse in Athletes: Detection and Consequences
Androgen Abuse in Athletes: Detection and Consequences
复制标题
DOI：
10.1210/jc.2009-1579
复制
发表时间：
2010-04-01
影响因子：
5.8
通讯作者：
Basaria, Shehzad
中科院分区：
文献类型：
--
作者：
Basaria, Shehzad
内容：兴奋剂与合成代谢雄激素类固醇（AAS）无论是在体育运动（特别是力量体育）和特定亚群的人口是猖獗的。随着设计师雄激素的供应越来越多，反兴奋剂机构需要做出重大努力，开发敏感的方法来检测其使用。证据获取：使用PubMed和Google Scholar搜索引擎来识别涉及各种形式兴奋剂的出版物，检测方法以及与其使用相关的不良影响。证据综合：世界反兴奋剂机构（WADA）禁止的药物清单在过去十年中有所增加。这个列表中的新条目包括促性腺激素，雌激素拮抗剂，芳香化酶抑制剂，雄激素前体和选择性雄激素受体调节剂。质谱的使用彻底改变了各种化合物的检测;然而，在识别新的设计师雄激素方面仍然存在挑战，因为它们的化学特征是未知的。高通量生物测定的发展可能是这个问题的答案。除了抑制精子发生、男性乳房发育和男性化之外，AAS的使用似乎仍然与过早死亡（尤其是心血管）有关。结论：雄激素滥用最近受到的关注应被用作教育运动员的机会和一般人群关于其不良影响。开发灵敏的检测技术可能有助于阻止（至少在某种程度上）滥用这些化合物。需要进行调查，以确定加速AAS用户性腺轴恢复的方法，并确定这些化合物对心脏损伤的机制。（临床内分泌代谢杂志95：1533-1543，2010）
Context: Doping with anabolic androgenic steroids (AAS) both in sports (especially power sports) and among specific subsets of the population is rampant. With increasing availability of designer androgens, significant efforts are needed by antidoping authorities to develop sensitive methods to detect their use.Evidence Acquisition: The PubMed and Google Scholar search engines were used to identify publications addressing various forms of doping, methods employed in their detection, and adverse effects associated with their use.Evidence Synthesis: The list of drugs prohibited by the World Anti-Doping Agency (WADA) has grown in the last decade. The newer entries into this list include gonadotropins, estrogen antagonists, aromatase inhibitors, androgen precursors, and selective androgen receptor modulators. The use of mass spectrometry has revolutionized the detection of various compounds; however, challenges remain in identifying newer designer androgens because their chemical signature is unknown. Development of high throughput bioassays may be an answer to this problem. It appears that the use of AAS continues to be associated with premature mortality (especially cardiovascular) in addition to suppressed spermatogenesis, gynecomastia, and virilization.Conclusion: The attention that androgen abuse has received lately should be used as an opportunity to educate both athletes and the general population regarding their adverse effects. The development of sensitive detection techniques may help discourage (at least to some extent) the abuse of these compounds. Investigations are needed to identify ways to hasten the recovery of the gonadal axis in AAS users and to determine the mechanism of cardiac damage by these compounds. (J Clin Endocrinol Metab 95: 1533-1543, 2010)