The female brain hypoestrogenic continuum from the premenstrual syndrome to menopause. A hypothesis and review of supporting data.
The female brain hypoestrogenic continuum from the premenstrual syndrome to menopause. A hypothesis and review of supporting data.
复制标题
从经前综合症到更年期的女性大脑低雌激素连续体。
DOI：
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发表时间：
1996
影响因子：
0.2
通讯作者：
J. C. Arpels
中科院分区：
文献类型：
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作者：
J. C. Arpels
目的
提出一个理论，以帮助统一经前综合征（PMS），产后忧郁和抑郁症，围绝经期过渡和更年期的症状。
研究设计
支持数据的审查是用来解释可能的神经内分泌机制的假设是基于。
结论
女性的大脑已被证明是雌激素的靶器官。共同的症状是共同的妇女抱怨经前综合症，产后忧郁，围绝经期过渡和更年期：抑郁，睡眠障碍，易怒，焦虑和恐慌，记忆和认知功能障碍和幸福感下降。抗雌激素孕酮、孕酮和他莫昔芬也可能引起这些相同的症状。有人提出，无论何时脑雌激素水平低于脑雌激素的最低要求，无论什么原因，在任何年龄，脑中枢功能障碍可能随之而来。
OBJECTIVE
To propose a theory to help unify the symptoms of premenstrual syndrome (PMS), postpartum blues and depression, the perimenopausal transition and menopause.
STUDY DESIGN
A review of supporting data is used to explain the possible neuroendocrine mechanism upon which the hypothesis is based.
CONCLUSION
The brain in women has been shown to be an estrogen target organ. Common symptoms are shared by women complaining of PMS, postpartum blues, the perimenopausal transition and menopause: depression, sleep disturbance, irritability, anxiety and panic, memory and cognitive dysfunction and a decreased sense of well-being. The antiestrogens progesterone, progestin and tamoxifen may also elicit these same symptoms. It is proposed that whenever brain estrogen levels fall below the minimum brain estrogen requirement, for whatever reason and at whatever age, brain center dysfunction may ensue.