Glutamate effect on synaptic transmission mediates neurotoxicity in dissociated rat hippocampal neurons.
Glutamate effect on synaptic transmission mediates neurotoxicity in dissociated rat hippocampal neurons.
复制标题
谷氨酸对突触传递的作用介导游离大鼠海马神经元的神经毒性。
DOI：
10.1016/0006-8993(94)01261-f
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Yoon,KW
中科院分区：
文献类型：
--
作者：
Yoon,KW
在分离的大鼠海马神经元中，缓慢浴（1 ml/min）谷氨酸（50 μM）增加兴奋性和抑制性突触活动。这种谷氨酸的作用被河豚毒素或镉消除。50 μM谷氨酸持续灌流1h对神经元有毒性作用。这种毒性也被TTX阻断。这表明，与高浓度（mM）下的兴奋性毒性不同，50 μM下的谷氨酸毒性是通过其对突触传递的影响介导的。
In dissociated rat hippocampal neurons, slow bath application (1 ml/min) of glutamate (50 μM) increased both excitatory and inhibitory synaptic activities. This glutamate effect was abolished by tetrodotoxin or cadmium. The constant perfusion (1 h) of glutamate 50 μM was toxic to the neurons. This toxicity was also blocked by TTX. This suggests that unlike the excitotoxicity at a high (mM) concentration, the glutamate toxicity at 50 μM is mediated by its effect on synaptic transmission.