The mechanics of setting up a COVID-19 response: Experiences of the COVID-19 epidemic from Groote Schuur Hospital, Cape Town, South Africa
The mechanics of setting up a COVID-19 response: Experiences of the COVID-19 epidemic from Groote Schuur Hospital, Cape Town, South Africa
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DOI：
10.7196/samj.2020.v110i10.15157
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发表时间：
2020-09-01
期刊：
影响因子：
--
通讯作者：
Wasserman, S
中科院分区：
文献类型：
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作者：
Mendelson, M;Booyens, L;Wasserman, S
SARS-CoV-2大流行给临床医生带来了巨大的挑战，即管理一种呼吸道病毒，这种病毒不仅能够引起严重肺炎和急性呼吸窘迫综合征，而且还会引起多系统疾病。临床研究的惊人步伐，特别是新疗法和重新定位疗法的适应性试验的激增，为这些疗法是否有效的问题提供了快速的答案，并导致皮质类固醇在需要氧气支持的住院患者的管理中占据了中心位置。一些治疗方式，如抗凝在预防和治疗潜在血栓栓塞并发症中的作用，以及在重症监护病房外使用高水平氧支持仍然存在争议。在这篇文章中，我们描述了在南非SARS-CoV-2疫情中心的主要三级医院格鲁特舒尔医院入院的COVID-19患者的临床管理。
The SARS-CoV-2 pandemic has presented clinicians with an enormous challenge in managing a respiratory virus that is not only capable of causing severe pneumonia and acute respiratory distress syndrome, but also multisystem disease. The extraordinary pace of clinical research, and particularly the surge in adaptive trials of new and repurposed treatments, have provided rapid answers to questions of whether such treatments work, and has resulted in corticosteroids taking centre stage in the management of hospitalised patients requiring oxygen support. Some treatment modalities, such as the role of anticoagulation to prevent and treat potential thromboembolic complications, remain controversial, as does the use of high-level oxygen support, outside of an intensive care unit setting. In this article, we describe the clinical management of COVID-19 patients admitted to Groote Schuur Hospital, a major tertiary level hospital at the epicentre of South Africa's SARS-CoV-2 epidemic during its first 4 months.