Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors
Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors
复制标题
太赫兹光纤扫描近场显微镜诊断乳腺肿瘤的性能
DOI：
10.1364/oe.19.019523
复制
发表时间：
2011-09-26
期刊：
影响因子：
3.8
通讯作者：
Sun, Chi-Kuang
中科院分区：
文献类型：
--
作者：
Chen, Hua;Lee, Wen-Jeng;Sun, Chi-Kuang
基于来自20名女性患者（平均年龄：53岁;范围：36 - 72岁）的组织，我们检查了室温操作的太赫兹（THz）光纤扫描近场显微镜诊断乳腺组织切片的性能。将标本冷冻切片，然后在解冻状态下进行测量，无需脱水。我们在320GHz下进行成像。我们的研究表明，在太赫兹透射照明模式下获得的图像都可以清楚地区分乳腺肿瘤组织和正常组织，而无需H & E染色。由于其能够进行定量分析，并允许后续染色和传统的病理组织学分析，我们的研究表明太赫兹光纤扫描近场显微镜在未来的自动化，这是至关重要的快速和完整的预筛选乳腺肿瘤病理检查和辅助快速定义的肿瘤边缘在手术过程中，如保乳手术的巨大潜力。(C)2011年美国光学学会
Based on tissues from 20 female patients (mean age: 53 years; rang: 36-72 years), we examine the performance of a room-temperature-operated terahertz (THz) fiber-scanning near-field microscopy to diagnose slices of breast tissues. The specimens were frozen sliced and then measured in a thawed state without dehydration. We performed the imaging at 320GHz. Our study indicates that images acquired in the THz transmission-illumination mode can all clearly distinguish breast tumor tissues from normal tissues without H&E staining. Due to its capability to perform quantitative analysis and to allow follow-up staining and traditional pathohistological analysis, our study indicates great potential of the THz fiber-scanning near-field microscopy for future automation, which is critical for fast and complete pre-screening on breast tumor pathological examinations and for assisting quick definition of the tumor margins during the surgical procedure such as breast-conserving surgery. (C) 2011 Optical Society of America