Effects of bisphenol A given neonatally on reproductive functions of male rats
Effects of bisphenol A given neonatally on reproductive functions of male rats
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DOI：
10.1016/j.reprotox.2005.10.003
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发表时间：
2006-07-01
影响因子：
3.3
通讯作者：
Iguchi, Taisen
中科院分区：
文献类型：
--
作者：
Kato, Hideo;Furuhashi, Tadakazu;Iguchi, Taisen
以雄性SD大鼠(CRJ：CD(IGS))为研究对象，观察双酚A(BPA)对其生殖参数的影响。从出生后第0天至第9天，皮下注射双酚A玉米油0.002~97 mg/kg体重或17β-雌二醇0.9 mg/kg，每天1次。观察包皮分离、交配率、受精率、精子分析、血清睾酮水平和睾丸基因表达。雌二醇组大鼠第10天睾丸重量减轻，睾丸雌激素介导的基因表达发生改变，150天包皮不完全分离后，交配率、睾丸和附属器官重量及精子数均下降。相比之下，所有BPA组的雄性都显示出正常的生殖参数。这些结果表明，在新生期给予雄性大鼠BPA既不影响生殖功能，也不会在睾丸中引发雌激素介导的基因反应。(C)2005 Elsevier Inc.保留所有权利。
Male Sprague-Dawley rats (Crj:CD (IGS) were treated neonatally with bisphenol A (BPA) to evaluate effects on reproductive parameters. Animals were given BPA subcutaneously in corn oil to dosages of 0.002-97 mg/kg body weight, or 0.9 mg/kg 17 beta-estradiol (E2) once a day from postnatal day (PND) 0 to PND 9. Preputial separation, copulatory rate, fertility rate, sperm analysis, serum testosterone levels, and gene expression in the testis were assessed. Males in the E2 group showed a decrease in testis weight and alterations of estrogen-mediated gene expression in the testis on PND 10, and by PND 150 incomplete preputial separation, decreases in the copulatory rate, testicular and accessory organ weights and number of sperm. In contrast, males in all BPA groups showed normal reproductive parameters. These results indicate that in male rats, BPA given during the neonatal period neither affected reproductive function nor evoked estrogen-mediated gene responses in the testis. (c) 2005 Elsevier Inc. All rights reserved.