Linked Social-Communication Dimensions and Connectivity in Functional Brain Networks in Autism Spectrum Disorder.
Linked Social-Communication Dimensions and Connectivity in Functional Brain Networks in Autism Spectrum Disorder.
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DOI：
10.1093/cercor/bhab057
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发表时间：
2021-04
期刊：
影响因子：
3.7
通讯作者：
Jinming Xiao;Huafu Chen;Xiaolong Shan;Changchun He;Ya Li;Xiaonan Guo;Heng Chen;W. Liao;L. Uddin;Xujun Duan
中科院分区：
文献类型：
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作者：
Jinming Xiao;Huafu Chen;Xiaolong Shan;Changchun He;Ya Li;Xiaonan Guo;Heng Chen;W. Liao;L. Uddin;Xujun Duan
最近的许多注意力集中在阐明社会互动-交流维度的结构，以及这些症状维度是否以及如何在自闭症谱系障碍(ASD)个体中彼此结合。然而，这些症状维度的潜在神经生物学基础尚不清楚，特别是社交和沟通维度与大脑网络的关联。在这里，我们提出了一种基于全脑网络的回归方法，以在大样本的ASD儿童中识别与这些症状维度相关的功能网络。基于连接组的预测模型(CPM)的建立是为了探索神经生物学证据，该证据支持沟通和社会互动缺陷合并为一个症状维度(社交/沟通缺陷)。结果表明，默认模式网络在沟通和社会互动维度中起核心作用。初级感觉知觉网络主要导致沟通障碍，高水平认知网络主要导致社会互动障碍。CPM发现，与这些症状维度相关的功能网络可以预测社交/沟通缺陷的合并维度。这些发现描绘了大脑功能网络与社交和沟通的症状维度之间的联系，并进一步提供了神经生物学证据，支持将沟通和社交缺陷合并为一个症状维度。
Much recent attention has been directed toward elucidating the structure of social interaction-communication dimensions and whether and how these symptom dimensions coalesce with each other in individuals with autism spectrum disorder (ASD). However, the underlying neurobiological basis of these symptom dimensions is unknown, especially the association of social interaction and communication dimensions with brain networks. Here, we proposed a method of whole-brain network-based regression to identify the functional networks linked to these symptom dimensions in a large sample of children with ASD. Connectome-based predictive modeling (CPM) was established to explore neurobiological evidence that supports the merging of communication and social interaction deficits into one symptom dimension (social/communication deficits). Results showed that the default mode network plays a core role in communication and social interaction dimensions. A primary sensory perceptual network mainly contributed to communication deficits, and high-level cognitive networks mainly contributed to social interaction deficits. CPM revealed that the functional networks associated with these symptom dimensions can predict the merged dimension of social/communication deficits. These findings delineate a link between brain functional networks and symptom dimensions for social interaction and communication and further provide neurobiological evidence supporting the merging of communication and social interaction deficits into one symptom dimension.