4′-N-methyl-5′-hydroxystaurosporine and 5′-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp strain
4′-N-methyl-5′-hydroxystaurosporine and 5′-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp strain
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DOI：
10.7164/antibiotics.53.895
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发表时间：
2000-09-01
影响因子：
3.3
通讯作者：
Grávalos, DG
中科院分区：
文献类型：
--
作者：
Hernández, LMC;Blanco, JAD;Grávalos, DG
从海洋小单孢菌L-31-CLCO-002菌株的培养液中分离到两个新的吲哚咔唑生物碱，即4 ′-N-甲基-5 ′-羟基星孢菌素（2）和5 ′-羟基星孢菌素（3）。给出了这些化合物对各种肿瘤细胞系的发酵、结构数据和细胞毒活性。
Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine (1) from the culture broth of a marine Micromonospora sp. (strain L-31-CLCO-002). The fermentation, structural data and cytotoxic activities of these compounds against various tumor cell lines are given.