Cyclodextrin inclusion complexes: Host-guest interactions and hydrogen-bonding networks
Cyclodextrin inclusion complexes: Host-guest interactions and hydrogen-bonding networks
复制标题
DOI：
10.1107/s0108767398010733
复制
发表时间：
1998-11-01
期刊：
影响因子：
--
通讯作者：
Steiner, T
中科院分区：
文献类型：
--
作者：
Saenger, W;Steiner, T
综述了α-、β-和γ-环糊精（CD）的结构特征。这些环状低聚糖由六个，七个和八个葡萄糖组成，与客体分子形成包合物，这些客体分子小到足以适合它们的中心空腔，并作为非共价键合的良好模型系统。根据大小和离子或分子性质的客人，复合物结晶笼或通道型结构。X射线和中子衍射已被用于研究分子间的相互作用;它们提供了对O-H的深入了解。O和C-H O氢键稳定大环构象和客体分子的包含。在CD水合物的晶格中，富含O-H基团，O-H基团之间形成协同网络。在β-CD大环中，观察到触发器类型的动力学无序，O-（1/2 H）…（1/2 H）-O，在相邻葡萄糖的O（2）-H和O（3）-H基团之间。
An overview is given on the structural characteristics of alpha-, beta- and gamma-cyclodextrins (CDs). These cyclic oligosaccharides consisting of six, seven and eight glucoses form inclusion complexes with guest molecules small enough to fit into their central cavities and serve as good model systems for non-covalent bonding. Depending on the size and the ionic or molecular nature of the guests, the complexes crystallize in cage- or channel-type structures. X-ray and neutron diffraction have been used to study intermolecular interactions; they provide insight into O-H .. O and C-H ... O hydrogen bonds stabilizing the macrocyclic conformations and the inclusion of the guest molecules. Throughout the crystal lattices of the CD hydrates, which abound with O-H groups, cooperative networks are formed by O--H ... O hydrogen bonds; in the beta-CD macrocycle, dynamic disorder of the flip-flop type is observed, O-(1/2H)...(1/2H)-O, between O(2)-H and O(3)-H groups of adjacent glucoses.