A minimal computational model for three-dimensional cell migration
A minimal computational model for three-dimensional cell migration
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DOI：
10.1098/rsif.2019.0619
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发表时间：
2019-12-01
影响因子：
3.9
通讯作者：
Rappel, Wouter-Jan
中科院分区：
文献类型：
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作者：
Cao, Yuansheng;Ghabache, Elisabeth;Rappel, Wouter-Jan
在迁移过程中，真核细胞可以不断改变其三维形态，这是一个高度动态和复杂的过程。使这一过程进一步复杂化的是，观察到相同的细胞类型可以在不同的迁移模式之间快速切换。模拟这种复杂性需要能够跟踪变形膜的模型，并且可以捕获负责迁移模式变化的细胞内动力学。在这里，我们开发了一个有效的三维细胞迁移计算模型，它将细胞力学与一个简单的细胞内激活物-抑制剂信号系统耦合在一起。我们将计算结果与使用社会变形虫盘齿龙的定量实验进行比较。该模型可以再现通过改变机械或生化模型参数产生的观察到的迁移模式，并表明底物和细胞的生物力学之间存在耦合。
During migration, eukaryotic cells can continuously change their three-dimensional morphology, resulting in a highly dynamic and complex process. Further complicating this process is the observation that the same cell type can rapidly switch between different modes of migration. Modelling this complexity necessitates models that are able to track deforming membranes and that can capture the intracellular dynamics responsible for changes in migration modes. Here we develop an efficient three-dimensional computational model for cell migration, which couples cell mechanics to a simple intracellular activator-inhibitor signalling system. We compare the computational results to quantitative experiments using the social amoeba Dictyostelium discoideum. The model can reproduce the observed migration modes generated by varying either mechanical or biochemical model parameters and suggests a coupling between the substrate and the biomechanics of the cell.