Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?
Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?
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DOI：
10.1016/s0968-0004(98)01200-6
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发表时间：
1998-06-01
影响因子：
13.8
通讯作者：
Wakelam, MJO
中科院分区：
文献类型：
--
作者：
Hodgkin, MN;Pettitt, TR;Wakelam, MJO
在真核生物中，许多受体激动剂使用磷脂酶产生的脂质作为细胞内信使。受体占据通过磷脂酰肌醇-4,5-二磷酸特异性磷脂酶 C 刺激多不饱和 1,2-二酰基甘油的产生，和/或通过磷脂酶-D 催化的磷脂酰胆碱分解产生单不饱和和饱和磷脂酸酯。初级磷脂酶产物快速代谢：多不饱和1,2-二酰甘油通过二酰甘油激酶转化为多不饱和磷脂酸酯；单不饱和和饱和磷脂通过磷脂酸磷酸水解酶去磷酸化，得到单不饱和和饱和1,2-二酰基甘油。磷脂酶产生的多不饱和 1,2-二酰基甘油以及单不饱和和饱和磷脂酸酯似乎是细胞内信使，而它们的直接代谢物可能不具有信号传导功能。
In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate-specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase products are rapidly metabolized: polyunsaturated 1,2-diacylglycerols are converted to polyunsaturated phosphatidates by diacylglycerol kinase; mono-unsaturated and saturated phosphatidates are dephosphorylated to give mono-unsaturated and saturated 1,2-diacylglycerols by phosphatidate phosphohydrolase. The phospholipase-generated polyunsaturated 1,2-diacylglycerols and mono-unsaturated and saturated phosphatidates appear to be intracellular messengers, whereas their immediate metabolites probably do not have signalling functions.