Neural damage associated with atopic diathesis
Neural damage associated with atopic diathesis
复制标题
与特应性素质相关的神经损伤
DOI：
10.1212/wnl.0b013e3181b6bb6b
复制
发表时间：
2009
期刊：
影响因子：
9.9
通讯作者：
Y. Kawano
中科院分区：
文献类型：
--
作者：
Noriko Isobe;Jun;N. Kawamura;T. Ishizu;Kimiyoshi Arimura;Y. Kawano
背景：我们以前报道过特应性疾病患者发生近视（特应性近视[AM]）。为了揭示与特应性相关的神经损伤谱，我们在全国范围内对特应性体质个体进行了AM和特应性相关周围神经炎（APN）（包括Churg-Strauss综合征（CSS））的横断面调查。方法：收集1996年至2006年诊断为AM的病例和2000年至2006年诊断为APN的病例。收集了109例AM和133例APN患者的详细资料。结果：APN患者中女性占优势，发病年龄较大，嗜酸性粒细胞计数高于AM患者。AM患者最常见的表现为颈髓受累，而APN患者优先表现为多发性单神经炎，主要累及下肢。在AM患者中，运动无力和肌肉萎缩在支气管哮喘患者中比其他特应性疾病患者更常见。符合CSS标准的APN患者与不符合CSS标准的患者相比，发病年龄更高，全身器官受累频率更高，残疾程度更大。提示周围神经系统受累的异常见于25.7%的AM患者，而18.8%的APN患者有提示CNS受累的异常。多因素Logistic回归分析显示，特应性皮炎增加了近视的风险，而发病年龄大和支气管哮喘降低了这种风险。结论：特应性神经炎是一种多灶性累及中枢神经系统和周围神经系统的疾病。先前的特应性疾病和年龄似乎影响神经损伤的分布。
Background: We previously reported the occurrence of myelitis in patients with atopic disorders (atopic myelitis [AM]). To uncover the spectrum of neural damage associated with atopy, we conducted a cross-sectional nationwide survey of AM and atopy-related peripheral neuritis (APN), including Churg–Strauss syndrome (CSS), in individuals with atopic diathesis. Method: Cases with AM diagnosed between 1996 and 2006 and cases with APN between 2000 and 2006 were collected from all over Japan. Detailed data on 109 patients with AM and 133 patients with APN were collated. Results: Patients with APN showed a preponderance of women, higher age at onset, and greater eosinophil counts than patients with AM. Patients with AM most commonly showed cervical cord involvement, whereas patients with APN preferentially exhibited mononeuritis multiplex predominantly affecting the lower limbs. Among patients with AM, motor weakness and muscle atrophy were significantly more frequent in those with bronchial asthma than in those with other atopic disorders. Patients with APN who met the criteria for CSS showed a higher age at onset, higher frequencies of systemic organ involvement, and greater disability than those who did not. Abnormalities suggesting peripheral nervous system involvement were seen in 25.7% of patients with AM, whereas 18.8% of patients with APN had abnormalities indicating CNS involvement. Multiple logistic regression analyses revealed that atopic dermatitis increased the risk of myelitis, whereas high age at onset and bronchial asthma decreased that risk. Conclusions: Atopy-related neural inflammation multifocally affects CNS and peripheral nervous system tissues. Both preceding atopic disorders and age seem to influence the distribution of neural damage.
DOI：
--
发表时间：
2008
期刊：
J Neurol Sci (in press)
影响因子：
--
作者：
Kira J;et. al.
通讯作者：
et. al.