Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill
Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill
复制标题
重症患者的经典和非经典肾素-血管紧张素系统
DOI：
10.1016/j.ccc.2018.11.002
复制
发表时间：
2019-04-01
影响因子：
4.3
通讯作者：
Burrell, Louise M.
中科院分区：
文献类型：
--
作者：
Bitker, Laurent;Burrell, Louise M.
经典和非经典的肾素-血管紧张素系统（RAS）是调节血压和体内平衡的普遍存在的内分泌/旁分泌级联的两个方面。血管紧张素II和血管紧张素转换酶（ACE）水平与危重病患者疾病的严重程度相关，并且是循环休克的生理学和发病机制的核心。血管紧张素（1-7）和ACE 2作为血管紧张素II/ACE轴的内源性反调节臂。基于组织的RAS具有与循环RAS分离的旁分泌效应。外源性血管紧张素II或ACE 2可分别改善感染性休克和急性呼吸窘迫综合征的预后。
Classic and nonclassic renin-angiotensin systems (RAS) are 2 sides of an ubiquitous endocrine/paracrine cascade regulating blood pressure and homeostasis. Angiotensin II and angiotensin-converting enzyme (ACE) levels are associated with severity of disease in the critically ill, and are central to the physiology and the pathogenesis of circulatory shock. Angiotensin (1-7) and ACE2 act as an endogenous counterregulatory arm to the angiotensin II/ACE axis. The tissue-based RAS has paracrine effects dissociated from those of the circulating RAS. Exogenous angiotensin II or ACE2 may improve the outcome of septic shock and acute respiratory distress syndrome, respectively.