The effect of sulpiride administration on maternal and fetal plasma prolactin levels, and fetal growth in rats.
The effect of sulpiride administration on maternal and fetal plasma prolactin levels, and fetal growth in rats.
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DOI：
10.1620/tjem.141.323
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发表时间：
1983-11
期刊：
影响因子：
--
通讯作者：
T. Fukaya;N. Furuhashi;H. Kono;O. Shinkawa;T. Takahashi;M. Suzuki
中科院分区：
文献类型：
--
作者：
T. Fukaya;N. Furuhashi;H. Kono;O. Shinkawa;T. Takahashi;M. Suzuki
从妊娠第 14 天开始，每天向怀孕 Wistar 大鼠腹膜腔注射 5 mg 舒必利。妊娠第20天从母体颈动脉和胎儿腋窝血管采集血样。使用大鼠 PRL RIA 试剂盒通过放射免疫测定法测定血清催乳素 (PRL) 水平。舒必利治疗组的母体血清和胎儿血浆PRL水平显着高于盐水对照组。胎儿体重与胎儿血浆PRL水平呈显着正相关。这些结果表明到达胎儿的舒必利刺激胎儿PRL的分泌并且PRL可能对胎儿发挥促进生长的作用。
Pregnant Wistar rats were daily injected with 5 mg sulpiride into the peritoneal cavity starting on day 14 of gestation. Blood samples were obtained from the maternal carotid artery and fetal axillary vessels on day 20 of gestation. Serum prolactin (PRL) levels were determined by radioimmunoassay using a rat PRL RIA kit. The maternal serum and fetal plasma PRL levels were significantly higher in the sulpiride-treated group than in the saline control group. There was a significant positive correlation between fetal body weight and fetal plasma PRL level. These results suggest that sulpiride which reached the fetus stimulates fetal PRL secretion and that PRL may exert a growth-promoting effect on the fetus.