Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia
Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia
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DOI：
10.1073/pnas.0504662102
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发表时间：
2005-07-26
影响因子：
11.1
通讯作者：
Webster, RG
中科院分区：
文献类型：
--
作者：
Hulse-Post, DJ;Sturm-Ramirez, KM;Webster, RG
野生水禽，包括鸭子，是甲型流感病毒的天然宿主。这些病毒很少在鸭子中引起疾病，直到 2002 年，一些 H5N1 病毒株变得具有高致病性。在这里，我们表明这些 H5N1 病毒正在鸭子中恢复为非致病性。鸭子实验性感染2003年至2004年分离的病毒后，会长时间（长达17天）释放病毒，在此期间选择了致病性较低的变异病毒。这些结果表明，鸭子已成为亚洲H5N1流感病毒的“特洛伊木马”。未受这些病毒感染影响的鸭子继续传播这些病毒，构成大流行威胁。
Wild waterfowl, including ducks, are natural hosts of influenza A viruses. These viruses rarely caused disease in ducks until 2002, when some H5N1 strains became highly pathogenic. Here we show that these H5N1 viruses are reverting to nonpathogenicity in ducks. Ducks experimentally infected with viruses isolated between 2003 and 2004 shed virus for an extended time (up to 17 days), during which variant viruses with low pathogenicity were selected. These results suggest that the duck has become the "Trojan horse" of Asian H5N1 influenza viruses. The ducks that are unaffected by infection with these viruses continue to circulate these viruses, presenting a pandemic threat.