Ferritinemia as an Indicator of Systemic Disease Activity in Children with Systemic Juvenile Rheumatoid Arthritis
Ferritinemia as an Indicator of Systemic Disease Activity in Children with Systemic Juvenile Rheumatoid Arthritis
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铁蛋白血症作为系统性幼年类风湿性关节炎儿童系统性疾病活动的指标
DOI：
10.1111/j.1651-2227.1986.tb10158.x
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
M. Siimes
中科院分区：
文献类型：
--
作者：
P. Pelkonen;K. Swanljung;M. Siimes
摘要。研究了20例全身性幼年类风湿性关节炎儿童（年龄0.9 - 13.7岁）在诊断时和2 - 9年随访期间的血清铁蛋白浓度。在诊断时，发烧期间，浓度极高。中位值为935 μg/l。这些值与疾病的其他表现或实验室检查结果无关。在糖皮质激素治疗期间，血清铁蛋白浓度迅速恢复正常，通常在几周内。正常化率反映了发热对治疗的反应。后来，发现了低于正常的浓度，这与关节炎的活动无关。因此，血清铁蛋白是减少糖皮质激素剂量的有用指南。
ABSTRACT. Twenty children with systemic juvenile rheumatoid arthritis, aged 0.9‐13.7 years, were studied with regard to their serum ferritin concentration at diagnosis and during follow‐up, ranging from 2 to 9 years. At diagnosis, during fever, the concentration was extremely high. The median value was 935 μg/l. The values were unrelated to other manifestations of the disease or laboratory findings. During glucocorticoid treatment, the serum ferritin concentrations normalized rapidly, usually within a few weeks. The rate of normalization reflected the response of the fever to treatment. Later, subnormal concentrations were found, which were unrelated to the activity of the arthritis. Thus, serum ferritin is a useful guide when tapering glucocorticoid dosage.