Brain mast cells link the immune system to anxiety-like behavior
Brain mast cells link the immune system to anxiety-like behavior
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DOI：
10.1073/pnas.0809479105
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发表时间：
2008-11-18
影响因子：
11.1
通讯作者：
Silver, Rae
中科院分区：
文献类型：
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作者：
Nautiyal, Katherine M.;Ribeiro, Ana C.;Silver, Rae
肥大细胞驻留在大脑中，含有许多介质，包括神经递质、细胞因子和趋化因子，这些介质会响应各种自然和药理触发因素而释放。大脑中肥大细胞的数量随着压力以及各种行为和内分泌状态而波动。这些特性表明肥大细胞有望影响神经系统的潜在行为。使用遗传和药理学功能丧失模型，我们对唤醒反应进行了行为筛选，包括情绪、运动和感觉成分。我们发现肥大细胞缺陷的 Kit(W-sh/W-sh) (sash(-/-)) 小鼠在旷场竞技场和高架十字迷宫中比 WT 和杂合子同窝对照动物具有更大的焦虑样表型。其次，我们发现，封锁大脑而不是外周肥大细胞的激活会增加焦虑样行为。总而言之，这些数据表明大脑肥大细胞参与了焦虑样行为的调节，并为神经免疫联系的行为重要性提供了证据。
Mast cells are resident in the brain and contain numerous mediators, including neurotransmitters, cytokines, and chemokines, that are released in response to a variety of natural and pharmacological triggers. The number of mast cells in the brain fluctuates with stress and various behavioral and endocrine states. These properties suggest that mast cells are poised to influence neural systems underlying behavior. Using genetic and pharmacological loss-of-function models we performed a behavioral screen for arousal responses including emotionality, locomotor, and sensory components. We found that mast cell deficient Kit(W-sh/W-sh) (sash(-/-)) mice had a greater anxiety-like phenotype than WT and heterozygote littermate control animals in the open field arena and elevated plus maze. Second, we show that blockade of brain, but not peripheral, mast cell activation increased anxiety-like behavior. Taken together, the data implicate brain mast cells in the modulation of anxiety-like behavior and provide evidence for the behavioral importance of neuroimmune links.