Engineered Niches to Analyze Mechanisms of Metastasis and Guide Precision Medicine.
Engineered Niches to Analyze Mechanisms of Metastasis and Guide Precision Medicine.
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DOI：
10.1158/0008-5472.can-20-0079
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发表时间：
2020-09-15
期刊：
影响因子：
11.2
通讯作者：
Shea LD
中科院分区：
文献类型：
--
作者：
Morris AH;Orbach SM;Bushnell GG;Oakes RS;Jeruss JS;Shea LD
癌症转移在临床和科学上都提出了一个具有挑战性的问题，因为转移性病变形成的随机性为临床前模型中的早期检测和转移研究引入了复杂性。工程转移壁龛代表了一种新兴的方法，以解决这种随机性，通过创建生物工程的网站，癌症可以优先转移。由于工程化的小生境在非重要位置捕获最早的转移细胞，因此可以常规地对这些部位进行非侵入性和基于活检的监测，以早期检测转移并监测形成的转移性小生境的变化。工程转移小生境还提供了一种新的平台技术，作为一个可调的网站，以分子解剖转移性疾病的机制。最终，将工程利基与传感器开发和合成生物学的进步联系起来，可以为临床前癌症模型提供支持工具，并增强影响临床癌症护理未来的潜力。
Cancer metastasis poses a challenging problem both clinically and scientifically, as the stochastic nature of metastatic lesion formation introduces complexity for both early detection and the study of metastasis in preclinical models. Engineered metastatic niches represent an emerging approach to address this stochasticity by creating bioengineered sites where cancer can preferentially metastasize. As the engineered niche captures the earliest metastatic cells at a non-vital location, both non-invasive and biopsy-based monitoring of these sites can be performed routinely to detect metastasis early and monitor alterations in the forming metastatic niche. The engineered metastatic niche also provides a new platform technology that serves as a tunable site to molecularly dissect metastatic disease mechanisms. Ultimately, linking the engineered niches with advances in sensor development and synthetic biology can provide enabling tools for preclinical cancer models and fosters the potential to impact the future of clinical cancer care.