Regulation and functional role of eEF1A2 in pancreatic carcinoma
Regulation and functional role of eEF1A2 in pancreatic carcinoma
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DOI：
10.1016/j.bbrc.2008.12.171
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发表时间：
2009-02-27
影响因子：
3.1
通讯作者：
Zhang, Yongping
中科院分区：
文献类型：
--
作者：
Cao, Haixia;Zhu, Qi;Zhang, Yongping
胰腺癌通常由于诊断较晚和缺乏治疗选择而预后不良。因此，更好地了解其病理机制和开发更有效的治疗方法是很重要的。长期以来，人们一直怀疑人类染色体20q13含有与胰腺癌和其他肿瘤有关的致癌基因。在本研究中，我们发现位于20q13的基因eEF1A2在胰腺癌中显著上调。在正常人类胰腺和慢性胰腺炎组织中检测到eEF1A2的表达很少或不表达，而在我们研究的83%的胰腺癌中，eEF1A2的表达增加。此外，通过体外和体内模型系统，我们发现eEF1A2的过表达促进了胰腺癌细胞的生长、存活和侵袭。因此，我们的数据表明，eEF1A2可能在胰腺癌发生中发挥重要作用，可能是作为肿瘤致癌基因。(C) 2009爱思唯尔公司版权所有。
Pancreatic cancer typically has all unfavourable prognosis due to late diagnosis and a lack of therapeutic options. Thus, it is important to better understand its pathological mechanism and to develop more effective treatments for the disease. Human chromosome 20q13 has long been suspected to harbour oncogenes involved in pancreatic cancer and other tumours. In this Study, we found that eEF1A2, a gene located in 20q13, was significantly upregulated in pancreatic cancer. Little or no expression of eEF1A2 was detected in normal human pancreatic and chronic pancreatitis tissues, whereas increased eEF1A2 expression occurred in 83% of the pancreatic cancers we studied, Furthermore, using in vitro and in vivo model systems, we found that overexpression of eEF1A2 promoted cell growth, survival, and invasion in pancreatic cancer. Our data thus suggest that eEF1A2 might play an important role in pancreatic carcinogenesis, possibly by acting as a tumour oncogene. (C) 2009 Elsevier Inc. All rights reserved.