Type IV collagen α6 chain-derived noncollagenous domain 1 (α6(IV)NC1) inhibits angiogenesis and tumor growth
Type IV collagen α6 chain-derived noncollagenous domain 1 (α6(IV)NC1) inhibits angiogenesis and tumor growth
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DOI：
10.1002/ijc.23269
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发表时间：
2008-04-15
影响因子：
6.4
通讯作者：
Kalluri, Raghu
中科院分区：
文献类型：
--
作者：
Mundel, Thomas M.;Yliniemi, Anna-Maija;Kalluri, Raghu
IV型胶原是血管基底膜的主要成分。几种IV型胶原蛋白的非胶原性(NC1)结构域显示出抑制血管生成和肿瘤生长的能力。在这里，我们证明了IV型胶原的α6链的NC1域(α6NC1)是血管生成和肿瘤生长的内源性抑制物。重组α6Nc1抑制人内皮细胞增殖和小鼠Matrigel栓新生血管α6NC1抑制皮下移植的Lewis肺癌的生长，也抑制在Rip1Tag2小鼠体内发展的自发性胰岛细胞瘤。抑制肿瘤生长与微血管密度显著降低有关。综上所述，我们的结果表明，α6NC1是血管生成和肿瘤生长的内源性抑制因子。(C)2007年Wiley-Liss，Inc.
Type IV collagen is a major component of vascular basement membranes. The noncollagenous (NC1) domains of several alpha-chains of type IV collagen reveal a capacity to inhibit angiogenesis and tumor growth. Here, we demonstrate that the NC1 domain of the alpha 6 chain of type IV collagen (alpha 6NC1) is an endogenous inhibitor of angiogenesis and tumor growth. Recombinant alpha 6NC1 inhibits human endothelial cell proliferation and neovascularization of Matrigel plugs in mice. The alpha 6NC1 suppresses the growth of subcutaneously transplanted Lewis lung carcinoma and also spontaneous pancreatic insulomas that develop in the Rip1Tag2 mice. Inhibition of tumor growth is associated with significantly diminished microvascular density. Collectively, our results demonstrate that alpha 6NC1 is an endogenous inhibitor of angiogenesis and tumor growth. (c) 2007 Wiley-Liss, Inc.