SERUM FATTY-ACIDS, APOLIPOPROTEINS, SELENIUM AND VITAMIN ANTIOXIDANTS AND THE RISK OF DEATH FROM CORONARY-ARTERY DISEASE
SERUM FATTY-ACIDS, APOLIPOPROTEINS, SELENIUM AND VITAMIN ANTIOXIDANTS AND THE RISK OF DEATH FROM CORONARY-ARTERY DISEASE
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DOI：
10.1016/0002-9149(85)90839-2
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发表时间：
1985-01-01
影响因子：
2.8
通讯作者：
PUSKA, P
中科院分区：
文献类型：
--
作者：
SALONEN, JT;SALONEN, R;PUSKA, P
对92名在5年随访期间死于冠心病的既往无心肌梗死患者和92名1：1配对的对照者进行了血清饱和脂肪酸、多不饱和脂肪酸、多不饱和脂肪酸、载脂蛋白AI和B、硒、维生素A和E浓度与冠心病死亡风险的独立相关性研究。病例-对照对来自随机抽取的. apprx人群样本。来自芬兰东部2个省的12，000名年龄在30-64岁之间的患者，该地区CAD死亡率非常高。对照组受试者的性别、年龄、血清胆固醇、平均动脉压、吸烟量和心血管疾病史相匹配。死于CAD的患者在随访前血清酯化花生四烯酸浓度低于对照组（41 vs 48 mg/l，P = 0.05），而对于无胸痛的患者，这种差异更大（36 vs 50 mg/l，P < 0.05）。血清多不饱和与饱和（P/S）脂肪酸比值≤ 0.28的人群中CAD死亡的校正风险（最低三分位数）为3.5倍（95%置信区间[Cl]，在多变量logistic模型中，与血清P/S比值较高的患者相比，（95% CI 1.6-19.8）对于没有胸痛或用力的配对。低血清载脂蛋白AI浓度（1.25 g/l或更低，在最低三分位数）与无胸痛人群中CAD死亡的校正风险相关2.5倍（95%CI 1.1-5.7）。血清硒、维生素A或维生素E浓度与CD死亡风险之间无一致相关性。
The independent association of serum concentrations of saturated and polyunsaturated and polyunsaturated fatty acids, apolipoproteins AI and B, Se and vitamins A and E with the risk of death from coronary artery disease (CAD) was studied in 92 persons with no previous myocardial infarction, who died from CAD during a 5-yr follow-up, and their 92 1-to-1 matched controls. Case-controls pairs came from a randomly drawn population sample of .apprx. 12,000 persons aged 30-64 yr from 2 provinces of eastern Finland, an area with exceptionally high CAD mortality. Control subjects were matched for sex, age, serum cholesterol, mean arterial pressure, tobacco consumption and history of cardiovascular diseases. The persons who died of CAD had lower serum esterified arachidonic acid concentrations before follow-up than the control subjects (41 vs 48 mg/l, P = 0.05), and this difference was greater for pairs with no chest pain on effort (36 vs. 50 mg/l, P < 0.05). The adjusted risk of CAD death in persons with a serum polyunsaturated to saturated (P/S) fatty acid ratio of 0.28 or less (in the lowest tertile) was 3.5-fold (95% confidence interval [Cl], 1.5-8.2) compared with those with higher serum P/S ratios in a multivariate logistic model and 5.6-fold (95% Cl 1.6-19.8) for pairs with no chest pain or effort. A low serum apolipoprotein AI concentration (1.25 g/l or less, in the lowest tertile) was associated with a 2.5-fold (95% Cl 1.1-5.7) adjusted risk of CAD death among the chest pain-free persons. No consistent association between serum Se, retinol or tocopherol concentrations and the risk of death from CD were found.