Diammonium glycyrrhizinate, a component of traditional Chinese medicine Gan-Cao, prevents murine T-cell-mediated fulminant hepatitis in IL-10- and IL-6-dependent manners
Diammonium glycyrrhizinate, a component of traditional Chinese medicine Gan-Cao, prevents murine T-cell-mediated fulminant hepatitis in IL-10- and IL-6-dependent manners
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甘草酸二铵是中药甘草的成分，通过 IL-10 和 IL-6 依赖性方式预防小鼠 T 细胞介导的暴发性肝炎
DOI：
10.1016/j.intimp.2007.05.011
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发表时间：
2007-10-01
影响因子：
5.6
通讯作者：
Tian, Zhigang
中科院分区：
文献类型：
--
作者：
Feng, Chen;Wang, Hengxiao;Tian, Zhigang
甘草酸二铵（DG）是一种传统中药（TCM），从甘草（Radix glycyrathae）中提取和纯化。根据临床实践，甘草因其抗炎作用而在肝炎的治疗中发挥着重要作用，但其潜在机制尚不清楚。在这项研究中，我们研究了 DG 保护小鼠免受刀豆蛋白 A 诱导的肝炎的机制。结果表明，腹腔注射DG可保护小鼠免受ConA诱导的血清ALT水平升高和肝细胞凋亡的影响；同时，肝脏NKT细胞和T细胞的绝对量显着下降，表明DG可以抑制淋巴细胞向肝脏的募集。此外，DG预处理提高了IL-6和IL-10的产生，表明DG可能通过两种途径保护肝脏免受损伤：通过IL-6依赖性方式直接保护肝细胞免于凋亡，以及通过IL-10依赖性方式间接抑制T细胞介导的炎症。 (c) 2007 Elsevier B.V. 保留所有权利。
Diammonium glycyrrhizinate (DG), a traditional Chinese medicine (TCM), is extracted and purified from liquorices (Radix glycyrrhizae). The liquorices exert an important function in the treatment of hepatitis because of its anti-inflammatory effects based upon the clinical practice, but the underlying mechanism is unclear. In this study, we investigated the mechanisms of DG in protecting mice from ConA-induced hepatitis. The results showed that intraperitoneal administration of DG protected mice against ConA-induced elevation of serum ALT levels and apoptosis of hepatocytes; at the same time, the absolute amount of hepatic NKT cells and T cells was significantly decreased, indicating that DG can inhibit the recruitment of lymphocytes into the liver. In addition, the production of IL-6 and IL-10 was improved by DG pretreatment, suggesting that DG may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way. (c) 2007 Elsevier B.V. All rights reserved.