Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls.
Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls.
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DOI：
10.1158/1055-9965.epi-08-0995
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Davis F
中科院分区：
文献类型：
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作者：
Il'yasova D;McCarthy B;Marcello J;Schildkraut JM;Moorman PG;Krishnamachari B;Ali-Osman F;Bigner DD;Davis F
由于胶质瘤的病因在很大程度上是未知的，胶质瘤风险与特应性疾病的负相关性是有希望的，值得密切关注。我们使用兄弟姐妹、朋友和基于诊所的对照研究了过敏史、哮喘和湿疹与胶质瘤风险之间的关系。该分析包括388例新发胶质瘤病例和80例兄弟姐妹，191例朋友和177例临床对照。通过网络或电话调查评估每例受试者的病史。根据条件（兄弟姐妹和朋友对照）和无条件（临床对照）logistic模型计算与过敏、哮喘、湿疹以及这些疾病总数相关的比值比（OR）及其95%置信区间。过敏与胶质瘤呈负相关：兄弟姐妹、朋友和临床对照组的OR分别为0.53（95%CI，0.15-1.84）、0.54（95%CI，0.28-1.07）和0.34（95%CI，0.23-0.50）。哮喘仅在与同胞对照组的比较中显示出负相关（OR=0.43; 95%CI，0.19-1.00）。仅在与朋友对照组的比较中，兴奋表现出负相关（OR=0.42; 95%CI，0.15-1.18）。这些疾病的总数（顺序评分0，1，2，3）与胶质瘤呈负相关：每增加一个特应性疾病，风险降低31-45%。当考虑不同的对照组时，这些估计值最稳定。将三个对照组中这些疾病的患病率与已发表的数据进行比较，我们注意到，基于临床的对照通常更好地近似于基于人群的患病率数据。这些对照似乎为以临床为中心的病例对照研究提供了合理的选择。
Because glioma etiology is largely unknown, the inverse association of glioma risk with atopic conditions is promising and deserves close scrutiny. We examined the association between a history of allergies, asthma, and eczema and glioma risk using sibling, friend, and clinic-based controls. This analysis included 388 incident glioma cases and 80 sibling, 191 friend, and 177 clinic-based controls. Each subject’s medical history was assessed via a web-based or telephone survey. Odds ratios (ORs) and their 95% confidence intervals for the associations with allergies, asthma, eczema, and the overall number of these conditions were calculated from conditional (for sibling and friend controls) and unconditional (for clinic-based controls) logistic models. Allergies were consistently inversely associated with the glioma: ORs were 0.53 (95% CI, 0.15–1.84), 0.54 (95% CI, 0.28–1.07), and 0.34 (95% CI, 0.23–0.50) with sibling, friend, and clinic-based controls, respectively. Asthma showed an inverse association only in the comparison with sibling controls (OR=0.43; 95% CI, 0.19–1.00). Eczema showed an inverse association only in the comparison with friend controls (OR=0.42; 95% CI, 0.15–1.18). The overall number of these conditions (ordinal score 0, 1, 2, 3) was inversely associated with glioma: The risk decreased 31–45% with each addition of an atopic condition. These estimates were the most stable when different control groups were considered. Comparing the prevalence of these conditions in the three control groups with published data, we note that clinic-based controls generally better approximate the prevalence data for population-based groups. These controls appear to present a reasonable choice for clinic-centered case-control studies.