GABA TRANSMISSION, BUT NOT BENZODIAZEPINE RECEPTOR STIMULATION, MODULATES ETHANOL INTAKE BY RATS
GABA TRANSMISSION, BUT NOT BENZODIAZEPINE RECEPTOR STIMULATION, MODULATES ETHANOL INTAKE BY RATS
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DOI：
10.1016/0741-8329(87)90087-5
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发表时间：
1987-11-01
期刊：
影响因子：
2.3
通讯作者：
BOISMARE, F
中科院分区：
文献类型：
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作者：
DAOUST, M;SALIGAUT, C;BOISMARE, F
选择成年雄性龙氏大鼠作为乙醇偏好大鼠（DR） 28 d。在这段时间之后，他们在14天内每天注射另一种药物：地西泮1毫克。Kg-1，阿普唑仑1毫克。Kg-1（苯二氮卓类药物），25mg .cntdot。kg-1 （GABA A和B激动剂），nipecotic酸150 mg .cntdot。kg-1 （GABA摄取抑制剂），muscimol 0.2 mg .cntdot。kg-1 （GABA A激动剂），AOAA 10 mg .cntdot。kg-1 （GABA脱羧酶抑制剂），巴氯芬3mg。kg-1 （GABA B激动剂），或NaCl 0.9% （1 ml/200 g）。在治疗期间，大鼠被隔离，自由获取食物，并在乙醇（12%）和水之间自由选择，每天分别记录其消费量。在处理中，只有AOAA和巴氯芬能显著降低乙醇摄入量，而不改变总液体摄入量。讨论了不同药物对GABA传递和乙醇摄入的影响。由此得出结论，GABA A和苯二氮卓类受体与乙醇摄入无关，但自愿乙醇摄入的调节可能与GABA代谢的改变和/或GABA B受体的刺激有关。GABA B受体对去甲肾上腺素能通路的干预作用也被唤起。
Adult male Long Evans were selected as ethanol preferring rats (DR) during 28 days. After this period, they were daily IP injected during 14 days with one of the next drugs: diazepam 1 mg .cntdot. kg-1, alprazolam 1 mg .cntdot. kg-1 (benzodiazepines), progabide 25 mg .cntdot. kg-1 (GABA A and B agonist), nipecotic acid 150 mg .cntdot. kg-1 (GABA uptake inhibitor), muscimol 0.2 mg .cntdot. kg-1 (GABA A agonist), AOAA 10 mg .cntdot. kg-1 (GABA decarboxylase inhibitor), baclofen 3 mg .cntdot. kg-1 (GABA B agonist), or NaCl 0.9% (1 ml/200 g). During treatments, rats were isolated, had free access to food, and free choice between ethanol (12%) and water whose respective consumption were daily noted. Among treatments, only AOAA and baclofen were able to decrease significantly ethanol intake, without modifying total liquid intake. The action of these different drugs on GABA transmission and on ethanol intake was discussed. It was concluded that GABA A and benzodiazepine receptors were not implicated in ethanol intake, but that modulation of voluntary ethanol intake could be associated with a modification of GABA metabolism and/or stimulation of GABA B receptors. An intervention of GABA B receptors on noradrenergic pathways was also evoked.