Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo.
Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo.
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DOI：
10.1039/c2cc30265a
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发表时间：
2012-04
影响因子：
4.9
通讯作者：
Yi Zhou;Ju-ying Li;Kai-Hui Chu;Ke-zhi Liu;Cheng Yao;Jingyun Li
中科院分区：
文献类型：
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作者：
Yi Zhou;Ju-ying Li;Kai-Hui Chu;Ke-zhi Liu;Cheng Yao;Jingyun Li
我们报告了三种用于检测次氯酸（HOCl）的新型水溶性二氢荧光素-醚探针FCN1、FCN2和FCN3，它们是基于特定的HOCl促进的氧化反应而设计的。这项工作还提供了一种使用斑马鱼模型监测特定细胞器中积累的次氯酸的有用方法。
We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on the basis of a specific HOCl-promoted oxidation reaction. This work also provided a useful method to monitor the accumulated HOCl in specific organelles using a zebrafish model.