Non-specific immunological determinations in Meniere's disease: any role in clinical practice?
Non-specific immunological determinations in Meniere's disease: any role in clinical practice?
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DOI：
10.1007/s00405-006-0147-2
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Marioni, Gino
中科院分区：
文献类型：
--
作者：
Savastano, Marina;Giacomelli, Luciano;Marioni, Gino
一些研究支持这样的假设，即自身免疫反应可能是梅尼埃病发生的致病因素。已证明内淋巴囊在免疫介导的反应中具有重要作用，并且免疫机制可能参与内淋巴积水的发展也变得明显。本研究的目的是分析血清学非特异性免疫试验在确定200例梅尼埃病患者免疫病理学可能作用中的有效性。通过测定红细胞沉降率（ESR）、C-反应蛋白水平、类风湿因子、血清免疫球蛋白水平（按组）、补体水平、淋巴细胞亚群、冷嘌呤、循环免疫复合物（CIC）、器官和非器官自身抗体，研究免疫活性。IG、ESR、C-反应蛋白、类风湿因子、补体组分和cryopulines的水平在所考虑的梅尼埃病患者队列中为阴性或不显著。另一方面，在超过一半的样本组中发现了高CIC值。关于T淋巴细胞亚群的数据表明，与T细胞毒性细胞相比，T辅助细胞明显增加，CD 4/CD 8比率增加。特别感兴趣的数据涉及T细胞活化复合物的分析。我们目前的研究结果表明，早期活化的T淋巴细胞的变化，特别是白细胞介素-2受体的表达发生变化。此外，似乎有可能将免疫学试验的改变与疾病的阶段相关联。目前的数据表明，免疫因素应被视为大多数梅尼埃病病例的相关因素。
Several studies supported the hypothesis that an autoimmune response may be a pathogenetic factor in Meniere's disease occurrence. It has been demonstrated that the endo-lymphatic sac has an important role in the immuno-mediated reaction and it has also become evident that an immunological mechanism may be involved in the development of endo-lymphatic hydrops. The present study was carried out in order to analyse the validity of serological non-specific immune tests in determining the possible role of immune pathology in 200 Meniere's suffering patients. The immune activity was investigated determining the erythrocyte sedimentation rate (ESR), the C-reactive protein levels, the rheumatoid factor, the serum immunoglobulin levels by group, the complement levels, the lymphocyte sub-populations, the cryoglobulines, the circulating immune complexes (CIC), organ and nonorgan auto-antibodies. Levels of Ig, ESR, C-reactive protein, rheumatoid factor, complement fractions and cryoglobulines were either negative or non-significant in the considered cohort of Meniere's disease suffering patients. On the other hand, in more than half of the sample group high values of CIC were found. Data concerning T-lymphocyte sub-population indicates a clear increase in T-helper compared to T-cytotoxic cells, with an increase in the CD4/CD8 ratio. The datum of particular interest concerns analysis of T-cells activation complexes. Our present findings show that early activated T-lymphocytes change and in particular changes occur in the expression of the interleukin-2 receptor. Moreover, it seems to be possible to correlate the alteration of the immunological tests and the phase of the disease. Present data showed that the immunological factor should be considered a relevant element in most of the cases of Meniere's disease.