Low-frequency stimulation of the tuberomammillary nucleus facilitates electrical amygdaloid-kindling acquisition in Sprague–Dawley rats
Low-frequency stimulation of the tuberomammillary nucleus facilitates electrical amygdaloid-kindling acquisition in Sprague–Dawley rats
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DOI：
10.1016/j.nbd.2008.07.002
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发表时间：
2008-10
影响因子：
6.1
通讯作者：
Deng-chang Wu;Zheng-bing Zhu-Ge;Chaoyang Yu;Qi Fang;Shuang Wang;Chun-lei Jin;Shihong Zhang;Zhong Ch
中科院分区：
文献类型：
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作者：
Deng-chang Wu;Zheng-bing Zhu-Ge;Chaoyang Yu;Qi Fang;Shuang Wang;Chun-lei Jin;Shihong Zhang;Zhong Ch
组胺在癫痫发作中起抑制作用。结节乳头核（TM）是脑中组胺能神经元的唯一所在地。为了确定TM的深部脑刺激（DBS）是否提供针对癫痫发作的保护，我们测试了低频刺激（LFS，1 Hz）、高频刺激（HFS，100 Hz）和TM的电解损伤对大鼠杏仁核点燃、戊四氮（PTZ）和最大电休克（MES）产生的癫痫发作的影响。TM的LFS加速行为发作阶段的进展，并增加在收购杏仁核点燃癫痫发作的平均后放电持续时间（ADD），但在完全点燃的动物没有相当大的抗惊厥作用。它也增强了MES诱导的癫痫发作，但对PTZ点燃的癫痫发作没有明显影响。此外，HFS和TM的双侧病变都加剧了杏仁核点燃癫痫发作的进展。这些结果表明，DBS的特定负位点存在于大脑中，如TM。本研究表明，选择合适的DBS靶点对癫痫的临床治疗至关重要。
Histamine plays a suppressive role in seizure. The tuberomammillary nucleus (TM) is the only locus of histaminergic neurons in the brain. To determine whether deep brain stimulation (DBS) of the TM provides protection against seizures, we tested the effects of low-frequency stimulation (LFS, 1 Hz), high frequency stimulation (HFS, 100 Hz), and electrolytic lesions of the TM on seizures generated by amygdaloid kindling, pentylenetetrazol (PTZ) and maximal electroshock (MES) in rats. LFS of TM accelerated the progression of behavioral seizure stage and increased the mean afterdischarge duration (ADD) during acquisition of amygdaloid-kindling seizures, but had no considerable anticonvulsive effect in fully kindled animals. It augmented the MES-induced seizures as well, but had no appreciable effects on PTZ-kindled seizures. In addition, both HFS and bilateral lesions of the TM exacerbated the progression of amygdaloid-kindling seizures. These results suggest that specific negative sites for DBS exist in the brain, such as the TM. This study indicates that it is crucial to choose a suitable target for DBS in the clinical treatment of epilepsy.