Anterior Insula Regulates Multiscale Temporal Organization of Sleep and Wake Activity.
Anterior Insula Regulates Multiscale Temporal Organization of Sleep and Wake Activity.
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DOI：
10.1177/0748730415627035
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发表时间：
2016-04
影响因子：
3.5
通讯作者：
Lu J
中科院分区：
文献类型：
--
作者：
Chen MC;Chiang WY;Yugay T;Patxot M;Özçivit İB;Hu K;Lu J
特定皮质区域在睡眠调节回路中的作用尚不清楚。前脑岛(AI)与觉醒和促进睡眠的下丘脑和脑干区域有很强的相互连接，我们假设AI调节睡眠和觉醒的模式。为了验证这一假设，我们对大鼠(n=8)的AI进行了损伤，并通过24小时睡眠记录和慢性红外活动监测，比较了这些动物和非损伤对照组(n=8)的睡眠、清醒和活动调节。与对照组相比，患有AI损伤的动物觉醒减少，快速眼动(REM)睡眠和非REM(NREM)睡眠增加。患有人工授精的动物的觉醒次数较短，特别是在活跃的黑暗阶段。人工智能损伤的动物也有更多的从NREM睡眠到REM睡眠的转换，特别是在不活跃的光阶段。慢性红外线监测显示，尽管昼夜节律完整，但AI损伤动物在多个时间尺度上运动活动的时间组织也受到干扰，在4-12小时内活动波动更随机。这些结果表明，人工智能调节睡眠和活动，并有助于在多个时间尺度上调节睡眠和运动行为的节律性。人工智能功能障碍可能是神经系统疾病睡眠-觉醒模式改变的基础。
The role of specific cortical regions in sleep-regulating circuits is unclear. The anterior insula (AI) has strong reciprocal connectivity with wake and sleep-promoting hypothalamic and brainstem regions, and we hypothesized that the AI regulates patterns of sleep and wakefulness. To test this hypothesis, we lesioned the AI in rats (n = 8) and compared sleep, wake, and activity regulation in these animals with nonlesioned controls (n = 8) with 24-h sleep recordings and chronic infrared activity monitoring. Compared to controls, animals with AI lesions had decreased wakefulness and increased rapid eye movement (REM) sleep and non-REM (NREM) sleep. AI-lesioned animals had shorter wake bouts, especially during the active dark phase. AI-lesioned animals also had more transitions from NREM to REM sleep, especially during the inactive light phase. Chronic infrared monitoring revealed that AI-lesioned animals also had a disturbed temporal organization of locomotor activity at multiple time scales with more random activity fluctuations from 4 to 12 h despite intact circadian rhythms. These results suggest that the AI regulates sleep and activity and contributes to the regulation of sleep and motor behavior rhythmicity across multiple time scales. Dysfunction of the AI may underlie changes in sleep-wake patterns in neurological diseases.