ENDOMETRIAL CANCER AND AGE AT LAST DELIVERY - EVIDENCE FOR AN ASSOCIATION
ENDOMETRIAL CANCER AND AGE AT LAST DELIVERY - EVIDENCE FOR AN ASSOCIATION
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DOI：
10.1093/oxfordjournals.aje.a115926
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发表时间：
1991-03-15
影响因子：
5
通讯作者：
SHAPIRO, S
中科院分区：
文献类型：
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作者：
LESKO, SM;ROSENBERG, L;SHAPIRO, S
由于激素和生殖因素在子宫内膜癌病因中所起的作用尚不完全清楚，作者评估了这种癌症的风险与上次分娩年龄的关系。 该数据是1978年至1985年间在美国和加拿大多家医院进行的一项以医院为基础的病例对照研究中获得的，该研究对483名患有子宫内膜癌的女性（病例）和693名患有其他疾病的女性（对照）进行了研究。最后一次分娩的年龄与子宫内膜癌风险之间存在负相关关系：与最后一次分娩在25岁之前的女性相比，比率为0.9（95％置信区间（Cl）） 25-29 岁末次分娩为 0.5-1.6)，30-34 岁末次分娩为 0.6 (95% Cl 0.3-1.0)，35-39 岁末次分娩为 0.5 (95% Cl 0.3-1.0)，40 岁或以上末次分娩为 0.4 (95% Cl 0.1-0.9)。 随着末次分娩年龄的增加，产率比下降的趋势具有统计学意义（p = 0.02）。 无论胎次或绝经状况如何，这种关联都很明显。 没有证据表明首次怀孕的年龄与风险之间存在关联。 这些数据表明，晚育的女性患子宫内膜癌的风险可能低于早育的女性。
Because the role hormonal and reproductive factors play in the etiology of endometrial cancer is incompletely understood, the authors evaluated the risk of this cancer in relation to age at last delivery. The data were obtained in a hospital-based case-control study of 483 women with endometrial cancer (cases) and 693 women with other conditions (controls) conducted in a number of hospitals in the United States and Canada from 1978 to 1985. There was an inverse association between age at last delivery and endometrial cancer risk: Compared with women who last gave birth before age 25 years, the rate ratio was 0.9 (95% confidence interval (Cl) 0.5-1.6) for last delivery at ages 25-29 years, 0.6 (95% Cl 0.3-1.0) for last delivery at ages 30-34 years, 0.5 (95% Cl 0.3-1.0) for last delivery at ages 35-39 years, and 0.4 (95% Cl 0.1-0.9) for last delivery at age 40 years or older. The trend of decreasing rate ratio with increasing age at last delivery was statistically significant (p = 0.02). The association was apparent regardless of parity or menopausal status. There was no evidence for an association between age at first pregnancy and risk. These data suggest that women who bear children late in reproductive life may be at lower risk for endometrial cancer than those who complete their families early.