Effect of quinidine on maintaining sinus rhythm after conversion of atrial fibrillation or flutter. A multicentre study from Stockholm.
Effect of quinidine on maintaining sinus rhythm after conversion of atrial fibrillation or flutter. A multicentre study from Stockholm.
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奎尼丁对心房颤动或扑动转变后维持窦性心律的影响。
DOI：
10.1136/hrt.37.5.486
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发表时间：
1975
影响因子：
--
通讯作者：
G. Rosenhamer
中科院分区：
文献类型：
--
作者：
T. Södermark;B. Jonsson;A. Olsson;L. Orö;H. Wallin;O. Edhag;A. Sjögren;M. Danielsson;G. Rosenhamer
在一项包括176名患者的对照研究中，发现Kinidin Durules形式的奎尼丁在成功电击转换后的1年随访期间显著降低了房颤的复发。一年后，奎尼丁组51%（52/101）的患者和对照组28%（21/75）的患者保持窦性心律（P <0.001）。不少于43%的患者在预期的DC转换之前，在使用硫酸奎尼丁维持剂量的治疗期间转换为窦性心律。胃肠道副作用并不少见，在某些情况下导致奎尼丁治疗中断。
In a controlled study comprising 176 patients, quinidine in the form of Kinidin Durules was found to reduced significantly the recurrence of the atrial fibrillation during a 1-year follow-up period after successful electric shock conversion. After one year, 51 per cent (52/101) of the patients in the quinidine group, and 28 per cent (21/75) in the control group remained in sinus rhythm (P smaller than 0.001). No less than 43 per cent of the patients converted to sinus rhythm during treatment with maintenance doses of quinidine sulphate before intended DC conversion. Gastrointestinal side-effects were not uncommon, and caused interruption of quinidine treatment in some cases.