Disseminated African histoplasmosis in an immunocompetent child in Burkina Faso: one case.
Disseminated African histoplasmosis in an immunocompetent child in Burkina Faso: one case.
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DOI：
10.7241/ourd.20133.91
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Lemasson, G.
中科院分区：
文献类型：
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作者：
Barro-Traore, F.;Sanwidi, M.;Lemasson, G.
前言：由组织胞浆菌变种引起的组织胞浆菌病。Duboisii在非洲是一种罕见的情感。局限性皮肤损害是最常见的形式。我们报告了一例免疫功能正常儿童的播散型。病例报告：一名8岁的学生因全身皮肤结节与严重的几乎所有关节的骨关节疼痛相关而住院。检查发现中度急性营养不良，多发性和皮下结节，粉红色和扁平丘疹，脐状丘疹，非常疼痛的结节状肿块，几个关节的肿块，多发性，坚固和活动性腺病，肝脾肿大和继发性痛性溃疡。多处骨骼在X光检查中受到影响。皮肤结节和脐状丘疹的组织学已鉴定出囊状血吸虫变种。杜伯西。在氟康唑治疗失败后，两性霉素B的演变一直是有利的。患者受益于南北合作和社会结构的帮助。结论：这一观察使我们能够描述1例播散性非洲组织胞浆菌病的临床和社会经济特征、诊断和治疗困难，并证明了两性霉素B的有效性。
Introduction: Histoplasmosis due to Histoplasma capsulatum var. duboisii is a rare affection in Africa. Localized cutaneous lesions are the most common form. We report a disseminated form in an immunocompetent child. Case report: An 8-year-old student has been hospitalized for generalized, cutaneous nodules associated with very severe osteo-articular pains of almost all the joints. The examination has noted a moderate acute malnutrition, multiple and sub-cutaneous nodules, pinkish and plan papules, umbilicate papules, very painful nodular tumefactions of several joints, multiple, firm and mobiles adenopathies, hepatosplenomegaly and secondary painful ulcerations. Multiple bones have been affected at the radiography. Histology of a cutaneous nodule and an umbilicate papule has identified H. capsulatum var. duboisii. After the failure of treatment with fluconazole, the evolution has been favourable with amphotericin B. The patient has benefited from collaboration North-South, the help of social structures. Conclusion: This observation allowed us to describe clinical and socio-economic characteristics, diagnostic and therapeutic difficulties of a case of disseminated African histoplasmosis and has demonstrated the effectiveness of amphotericin B.