ASSOCIATION OF SERUM ANTI-NEURAMINIDASE ANTIBODY WITH RESISTANCE TO INFLUENZA IN MAN
ASSOCIATION OF SERUM ANTI-NEURAMINIDASE ANTIBODY WITH RESISTANCE TO INFLUENZA IN MAN
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DOI：
10.1056/nejm197206222862502
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发表时间：
1972-01-01
影响因子：
158.5
通讯作者：
CHANOCK, RM
中科院分区：
文献类型：
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作者：
MURPHY, BR;KASEL, JA;CHANOCK, RM
通过向志愿者注射野生型甲型流感/香港/1968 (H3N2) 病毒来研究血清抗神经氨酸酶抗体在抵抗流感疾病中的作用，这些志愿者拥有不同水平的这种抗体，但缺乏针对该病毒的血凝素表面抗原的抗体。对野生型病毒的临床反应与血清抗神经氨酸酶抗体的水平有关。患有流感疾病并发烧的志愿者在攻击前血清抗体水平较低，而经历隐性感染的男性神经氨酸酶抗体平均水平明显较高。那些患有非发热性疾病的人具有中等水平的抗神经氨酸酶抗体。病毒排泄持续时间和最大病毒排出水平也与血清抗神经氨酸酶抗体滴度呈负相关。这些发现提供了证据表明针对流感神经氨酸酶的抗体与人类对甲型流感病毒临床表达的抗性相关。
The role of serum anti-neuraminidase antibody in resistance to influenzal illness was investigated by administration of wild-type influenza A/Hong Kong/1968 (H3N2) virus to volunteers who possessed varying levels of this antibody but who lacked antibody for the hemagglutinin surface antigen of the virus. Clinical response to the wild-type virus was related to the level of serum anti-neuraminidase antibody. Volunteers in whom influenzal disease with fever developed possessed low levels of serum antibody prior to challenge, whereas men who underwent inapparent infection had a significantly higher mean level of antibody for neuraminidase. Those with afebrile illness had an intermediate level of anti-neuraminidase antibody. Duration of virus excretion and maximal level of virus shed were also inversely related to the titer of serum anti-neuraminidase antibody. These findings provide evidence that antibody directed against influenzal neuraminidase is associated with resistance to clinical expression of influenza A virus in man.